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Control of Advanced Cancer: The Road to Chronicity
Centre of Molecular Immunology, P.O. Box 16040, Havana City 11600, Cuba
* Author to whom correspondence should be addressed.
Received: 28 December 2010; in revised form: 28 January 2011 / Accepted: 11 February 2011 / Published: 1 March 2011
Abstract: Despite the recent trend toward a slight decrease in age-adjusted cancer mortality in some countries, crude mortality rates will continue to increase, driven by the demographic shift towards an aged population. Small molecules (small molecules and biologics) are not only a new therapeutic acquisition, but the tools of a more fundamental transition: the transformation of cancer from a rapidly fatal disease into a chronic condition. Antibodies and cancer vaccines can be used for a long time, even beyond progressive disease, and in aged patients, usually unfit for more aggressive conventional treatments. However, this transition to chronicity will require novel developmental guidelines adequate to this kind of drugs, for which optimal dose is not usually the maximal tolerated dose, pharmacokinetics does not define treatment schedule, and tumor shrinkage is not a good correlate of survival. The ongoing cancer immunotherapy program (including several monoclonal antibodies and therapeutic vaccines) at the Centre of Molecular Immunology can illustrate the issues to be addressed, both biological and social, along the path to transform advanced cancer into a chronic non-communicable disease compatible with years of quality life.
Keywords: advanced cancer; chronic treatment; small molecules; biotechnology
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Cite This Article
MDPI and ACS Style
Lage, A.; Crombet, T. Control of Advanced Cancer: The Road to Chronicity. Int. J. Environ. Res. Public Health 2011, 8, 683-697.
Lage A, Crombet T. Control of Advanced Cancer: The Road to Chronicity. International Journal of Environmental Research and Public Health. 2011; 8(3):683-697.
Lage, Agustin; Crombet, Tania. 2011. "Control of Advanced Cancer: The Road to Chronicity." Int. J. Environ. Res. Public Health 8, no. 3: 683-697.