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Int. J. Environ. Res. Public Health 2010, 7(4), 1760-1772; doi:10.3390/ijerph7041760
Review

Maternal Diet, Behaviour and Offspring Skeletal Health

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Received: 24 December 2009 / Revised: 10 March 2010 / Accepted: 15 April 2010 / Published: 16 April 2010
(This article belongs to the Special Issue Health Behavior and Public Health)
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Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
Keywords: osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Goodfellow, L.R.; Earl, S.; Cooper, C.; Harvey, N.C. Maternal Diet, Behaviour and Offspring Skeletal Health. Int. J. Environ. Res. Public Health 2010, 7, 1760-1772.

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