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Maternal Diet, Behaviour and Offspring Skeletal Health
Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
* Author to whom correspondence should be addressed.
Received: 24 December 2009; in revised form: 10 March 2010 / Accepted: 15 April 2010 / Published: 16 April 2010
Abstract: Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
Keywords: osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus
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MDPI and ACS Style
Goodfellow, L.R.; Earl, S.; Cooper, C.; Harvey, N.C. Maternal Diet, Behaviour and Offspring Skeletal Health. Int. J. Environ. Res. Public Health 2010, 7, 1760-1772.
Goodfellow LR, Earl S, Cooper C, Harvey NC. Maternal Diet, Behaviour and Offspring Skeletal Health. International Journal of Environmental Research and Public Health. 2010; 7(4):1760-1772.
Goodfellow, Laura R.; Earl, Susannah; Cooper, Cyrus; Harvey, Nicholas C. 2010. "Maternal Diet, Behaviour and Offspring Skeletal Health." Int. J. Environ. Res. Public Health 7, no. 4: 1760-1772.