Next Article in Journal
Heterogeneous Trajectories of Physical and Mental Health in Late Middle Age: Importance of Life-Course Socioeconomic Positions
Previous Article in Journal
Functional Coping Dynamics and Experiential Avoidance in a Community Sample with No Self-Injury vs. Non-Suicidal Self-Injury Only vs. Those with Both Non-Suicidal Self-Injury and Suicidal Behaviour
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(6), 576; doi:10.3390/ijerph14060576

The Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)

1
Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China
2
Animals, Plants and Food Testing Center of Tianjin Exit-Entry Inspection & Quarantine Bureau, Tianjin 300461, China
3
Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazards, Logistics University of Chinese People’s Armed Police Forces, No. 1, Hui-Zhi Ring Road, Tianjin 300309, China
*
Author to whom correspondence should be addressed.
Received: 1 May 2017 / Revised: 23 May 2017 / Accepted: 25 May 2017 / Published: 29 May 2017
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [1837 KB, uploaded 30 May 2017]   |  

Abstract

Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ecosystems are recognized as reservoirs for antibiotic resistant bacteria (ARB) and ARGs. In this study, a qPCR assay was developed to monitor and quantify the mcr-1 gene in the Haihe River, China. The results showed that all 18 samples collected from different locations over 6 months along the Haihe River were positive for the mcr-1 gene, and the highest level of mcr-1 reached 3.81 × 105 gene copies (GC) per liter of water. This is the first study to quantify mcr-1 in a natural water system by qPCR. Our findings highlight the potential for this antibiotic resistance determinant to spread extensively, suggesting a significant health and ecological impact. View Full-Text
Keywords: colistin-resistance gene; mcr-1; water environments; dissemination; public health colistin-resistance gene; mcr-1; water environments; dissemination; public health
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yang, D.; Qiu, Z.; Shen, Z.; Zhao, H.; Jin, M.; Li, H.; Liu, W.; Li, J.-W. The Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China). Int. J. Environ. Res. Public Health 2017, 14, 576.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top