Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model
AbstractBackground: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. Methods: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18–45 years using a case-only design in a cohort of women with VTE. Women with a VTE event after 45 years of age were censored and contributed only follow-up time. Results: We identified two intragenic single nucleotide polymorphisms (SNPs) at genome-wide significance in the PURB gene located on chromosome 7, and two additional intragenic SNPs, one in the LINGO2 gene on chromosome 9 and one in RDXP2 on chromosome X. Conclusions: We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum). View Full-Text
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de Andrade, M.; Armasu, S.M.; McCauley, B.M.; Petterson, T.M.; Heit, J.A. Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. Int. J. Environ. Res. Public Health 2017, 14, 1228.
de Andrade M, Armasu SM, McCauley BM, Petterson TM, Heit JA. Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. International Journal of Environmental Research and Public Health. 2017; 14(10):1228.Chicago/Turabian Style
de Andrade, Mariza; Armasu, Sebastian M.; McCauley, Bryan M.; Petterson, Tanya M.; Heit, John A. 2017. "Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model." Int. J. Environ. Res. Public Health 14, no. 10: 1228.
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