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Int. J. Environ. Res. Public Health 2016, 13(9), 869; doi:10.3390/ijerph13090869

Phytoestrogens and Mycoestrogens Induce Signature Structure Dynamics Changes on Estrogen Receptor α

1
Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA
2
Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843, USA
3
Department of Molecular Biology and Genetics, Karadeniz Technical University, Trabzon 61080, Turkey
4
Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843, USA
5
Office of the Taxes State Chemist, Texas A&M University, College Station, TX 77843, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 10 July 2016 / Revised: 15 August 2016 / Accepted: 23 August 2016 / Published: 31 August 2016
(This article belongs to the Special Issue Endocrine Disruptors and Public Health)
View Full-Text   |   Download PDF [1690 KB, uploaded 31 August 2016]   |  

Abstract

Endocrine disrupters include a broad spectrum of chemicals such as industrial chemicals, natural estrogens and androgens, synthetic estrogens and androgens. Phytoestrogens are widely present in diet and food supplements; mycoestrogens are frequently found in grains. As human beings and animals are commonly exposed to phytoestrogens and mycoestrogens in diet and environment, it is important to understand the potential beneficial or hazardous effects of estrogenic compounds. Many bioassays have been established to study the binding of estrogenic compounds with estrogen receptor (ER) and provided rich data in the literature. However, limited assays can offer structure information with regard to the ligand/ER complex. Our current study surveys the global structure dynamics changes for ERα ligand binding domain (LBD) when phytoestrogens and mycoestrogens bind. The assay is based on the structure dynamics information probed by hydrogen deuterium exchange mass spectrometry and offers a unique viewpoint to elucidate the mechanism how phytoestrogens and mycoestrogens interact with estrogen receptor. The cluster analysis based on the hydrogen deuterium exchange (HDX) assay data reveals a unique pattern when phytoestrogens and mycoestrogens bind with ERα LBD compared to that of estradiol and synthetic estrogen modulators. Our study highlights that structure dynamics could play an important role in the structure function relationship when endocrine disrupters interact with estrogen receptors. View Full-Text
Keywords: estrogen receptor; phytoestrogen; mycoestrogen; structure dynamics; mass spectrometry estrogen receptor; phytoestrogen; mycoestrogen; structure dynamics; mass spectrometry
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Chen, X.; Uzuner, U.; Li, M.; Shi, W.; Yuan, J.S.; Dai, S.Y. Phytoestrogens and Mycoestrogens Induce Signature Structure Dynamics Changes on Estrogen Receptor α. Int. J. Environ. Res. Public Health 2016, 13, 869.

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