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Int. J. Environ. Res. Public Health 2016, 13(2), 224; doi:10.3390/ijerph13020224

Environmental Exposure to Triclosan and Semen Quality

1
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2
MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
3
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032, China
4
Department of Science and Research, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China
5
Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 December 2015 / Revised: 22 January 2016 / Accepted: 4 February 2016 / Published: 17 February 2016
(This article belongs to the Special Issue Endocrine Disruptors and Public Health)
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Abstract

Triclosan (2,4,4′-trichloro-2′-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine)−1 (interquartile range, 0.41–2.95 ng (mg·creatinine)−1). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient β = −0.17; 95% confidence interval (CI) (−0.32, −0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (β = −0.35; 95% CI (−0.68, −0.03)), percentage of sperms with normal morphology (β = −1.64; 95% CI (−3.05, −0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings. View Full-Text
Keywords: cross-sectional study; semen quality; triclosan; endocrine disruptor cross-sectional study; semen quality; triclosan; endocrine disruptor
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MDPI and ACS Style

Zhu, W.; Zhang, H.; Tong, C.; Xie, C.; Fan, G.; Zhao, S.; Yu, X.; Tian, Y.; Zhang, J. Environmental Exposure to Triclosan and Semen Quality. Int. J. Environ. Res. Public Health 2016, 13, 224.

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