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Int. J. Environ. Res. Public Health 2016, 13(2), 176; doi:10.3390/ijerph13020176

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China

Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 3 January 2016 / Revised: 19 January 2016 / Accepted: 25 January 2016 / Published: 28 January 2016
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Abstract

Objective: To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. Methods: A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1) The genotypic and allelic frequencies of rs2515602, rs2230806 and rs4149313 were different between normal HDL-C and low HDL-C subjects, the genotypic frequency of rs2275542 was also different between normal HDL-C and low HDL-C subjects (p < 0.05); (2) the level of HDL-C (rs2515602 and rs2275542) in normal HDL-C subjects were different among the genotypes (p < 0.05); the levels of TC, LDL-C (rs2515602, rs4149313); TG (rs2515602, rs1800976, rs4149313) in low HDL-C patients were different among the genotypes (p < 0.05); (3) interactions between the rs3890182, rs2275542, rs180096, and rs4149313 polymorphisms in ABCA1 gene and obesity may be associated with low HDL-C disease; (4) the C-C-C-A-A-G, T-C-C-A-A-A, T-C-C-A-A-G, C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes were significant between the subjects with normal HDL-C and low HDL-C level (p < 0.05). Conclusions: The differences in serum lipid levels between normal HDL-C and low HDL-C subjects among Kazakhs might partly result from ABCA1 gene polymorphisms; ABCA1 gene polymorphisms may be associated with low HDL-C disease; the low HDL-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity; the C-C-C-A-A-G, T-C-C-A-A-A, and T-C-C-A-A-G haplotypes may serve as risk factors of low HDL-C disease among Kazakhs, the C-C-C-A-A-A, C-T-G-G-A-A, and T-T-C-G-A-A haplotypes may serve as protective factor of low HDL-C disease among Kazakhs. View Full-Text
Keywords: ABCA1; obesity; interaction; low HDL-C; Kazakh ABCA1; obesity; interaction; low HDL-C; Kazakh
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yao, M.-H.; Guo, H.; He, J.; Yan, Y.-Z.; Ma, R.-L.; Ding, Y.-S.; Zhang, J.-Y.; Liu, J.-M.; Zhang, M.; Li, S.-G.; Xu, S.-Z.; Niu, Q.; Ma, J.-L.; Guo, S.-X. Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China. Int. J. Environ. Res. Public Health 2016, 13, 176.

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