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Int. J. Environ. Res. Public Health 2016, 13(11), 1067; doi:10.3390/ijerph13111067

Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

1
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
2
IOS, Southern Italy Hospital Institute, Medicina Futura Research, Naples 80100, Italy
3
Centre for Primary Care and Public Health, Queen Mary University of London, London E1 4NS, UK
4
IRCCS SDN Istituto di Ricerca Diagnostica e Nucleare, Naples 80133, Italy
5
St. Peter’s Fatebenefratelli Hospital, Rome 00186, Italy
6
Department of Orthopaedic Surgery and Rehabilitation, Second University of Naples, Naples 81100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 27 July 2016 / Revised: 19 October 2016 / Accepted: 24 October 2016 / Published: 1 November 2016
(This article belongs to the Special Issue Environmental Diseases)
View Full-Text   |   Download PDF [299 KB, uploaded 1 November 2016]

Abstract

Objectives: We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods: We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors. Results: Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m2. Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (p < 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05–1.83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI. Conclusions: Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis. View Full-Text
Keywords: diabetes; obesity; environmental factors; osteoporosis; fractures; quantitative ultrasounds diabetes; obesity; environmental factors; osteoporosis; fractures; quantitative ultrasounds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Neglia, C.; Argentiero, A.; Chitano, G.; Agnello, N.; Ciccarese, R.; Vigilanza, A.; Pantile, V.; Argentiero, D.; Quarta, R.; Rivezzi, M.; Di Tanna, G.L.; Di Somma, C.; Migliore, A.; Iolascon, G.; Gimigliano, F.; Distante, A.; Piscitelli, P. Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure. Int. J. Environ. Res. Public Health 2016, 13, 1067.

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