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Int. J. Environ. Res. Public Health 2016, 13(10), 969; doi:10.3390/ijerph13100969

l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

1
Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
2
Sports Science Research Institute of Jilin Province, Changchun 130022, China
3
The China-Japan Union Hospital of Jilin University, Changchun 130033, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Matthew Lee Smith and Marcia G. Ory
Received: 4 May 2016 / Revised: 23 August 2016 / Accepted: 20 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Aging and Health Promotion)
View Full-Text   |   Download PDF [1500 KB, uploaded 29 September 2016]   |  

Abstract

The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate. View Full-Text
Keywords: C. elegans; l-Arg; antiaging; antioxidant; free radical C. elegans; l-Arg; antiaging; antioxidant; free radical
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Ma, H.; Ma, Y.; Zhang, Z.; Zhao, Z.; Lin, R.; Zhu, J.; Guo, Y.; Xu, L. l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans. Int. J. Environ. Res. Public Health 2016, 13, 969.

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