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Int. J. Environ. Res. Public Health 2015, 12(7), 8332-8347; doi:10.3390/ijerph120708332

Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice

1
Department of Pharmacy, Qinghai University Medical College, Xining 810001, China
2
Department of Radiotherapy Oncology, Qinghai University Affiliated Hospital, Xining 810001, China
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 15 May 2015 / Revised: 29 June 2015 / Accepted: 2 July 2015 / Published: 17 July 2015
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Abstract

The protective effect of Lycium ruthenicum Murr. against radiation injury was examined in mice. Kunming mice were randomly divided into a control group, model group, positive drug group and L. ruthenicum high dose (8 g/kg), L. ruthenicum middle dose (4 g/kg), L. ruthenicum low dose (2 g/kg) treatment groups, for which doses were administered the third day, seventh day and 14th day after irradiation. L. ruthenicum extract was administered orally to the mice in the three treatment groups and normal saline was administered orally to the mice in the control group and model group for 14 days. The positive group was treated with amifostine (WR-2721) at 30 min before irradiation. Except for the control group, the groups of mice received a 5 Gy quantity of X-radiation evenly over their whole body at one time. Body weight, hemogram, thymus and spleen index, DNA, caspase-3, caspase-6, and P53 contents were observed at the third day, seventh day, and 14th day after irradiation. L. ruthenicum could significantly increase the total red blood cell count, hemoglobin count and DNA contents (p < 0.05). The spleen index recovered significantly by the third day and 14th day after irradiation (p < 0.05). L. ruthenicum low dose group showed a significant reduction in caspase-3 and caspase-6 of serum in mice at the third day, seventh day, and 14th day after irradiation and L. ruthenicum middle dose group experienced a reduction in caspase-6 of serum in mice by the seventh day after irradiation. L. ruthenicum could decrease the expression of P53. The results showed that L. ruthenicum had protective effects against radiation injury in mice. View Full-Text
Keywords: Lycium ruthenicum Murr.; radioprotection; apoptosis; hematopoietic Lycium ruthenicum Murr.; radioprotection; apoptosis; hematopoietic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Duan, Y.; Chen, F.; Yao, X.; Zhu, J.; Wang, C.; Zhang, J.; Li, X. Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice. Int. J. Environ. Res. Public Health 2015, 12, 8332-8347.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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