Next Article in Journal
Cost-Effectiveness of a New Nordic Diet as a Strategy for Health Promotion
Previous Article in Journal
Extremely Low Frequency Magnetic Field Exposure and Parkinson’s Disease—A Systematic Review and Meta-Analysis of the Data
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2015, 12(7), 7357-7369; doi:10.3390/ijerph120707357

Cross-Sectional Study of Hepatitis A Virus Infection in the Pantanal Population before Vaccine Implementation in Brazil: Usage of Non-Invasive Specimen Collection

1
Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz-FIOCRUZ, Cx Postal 926. Av., Brasil 4365, CEP: 21045-900 Rio de Janeiro/RJ, Brazil
2
Laboratório de Hepatites Virais, Instituto Oswaldo Cruz-FIOCRUZ, Cx Postal 926. Av., Brasil 4365, CEP: 21045-900 Rio de Janeiro/RJ, Brazil
3
Departamento de Farmácia Bioquímica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Cx Postal 549, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 13 April 2015 / Revised: 21 May 2015 / Accepted: 25 May 2015 / Published: 30 June 2015
View Full-Text   |   Download PDF [855 KB, uploaded 30 June 2015]   |  

Abstract

Population-based prevalence studies are essential tools for screening of hepatitis A and provide important data on susceptible groups. However, surveillance in isolated communities is difficult because of the limited access to these areas and the need for blood sample collection. This study aimed to determine the anti-HAV prevalence using oral fluid samples to provide an alternative tool for epidemiological studies that might be useful for vaccination-related decisions. The study population was composed of 224 volunteers from South Pantanal, aged 3 to 86 years old. This study was performed using oral fluids, previously standardized for anti-HAV antibody detection, which were collected using a ChemBio device. Eluates were tested using modified commercial EIA to detect anti-HAV antibodies. The overall prevalence was 79.1%, corresponding to 178 reactive EIA tests out of 224 samples. The age stratified data revealed a prevalence of 47.8% between 0–10 years, 84% in 11–20 years and 91.9% in subjects older than 21 years. Results indicate that hepatitis A prevalence was higher in adolescents and adults, corroborating the literature reports. Thus, oral fluid samples could replace serum in HAV epidemiological studies in isolated communities as they are efficient at detecting anti-HAV antibodies. View Full-Text
Keywords: hepatitis A; epidemiology; oral fluid; vaccine hepatitis A; epidemiology; oral fluid; vaccine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tourinho, R.S.; de Almeida, A.J.; Villar, L.M.; Murat, P.G.; Capelin, G.J.M.; Castro, A.R.C.M.; de Paula, V.S. Cross-Sectional Study of Hepatitis A Virus Infection in the Pantanal Population before Vaccine Implementation in Brazil: Usage of Non-Invasive Specimen Collection. Int. J. Environ. Res. Public Health 2015, 12, 7357-7369.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top