Next Article in Journal
Acute Effects of Exposure to a Traditional Rural Environment on Urban Dwellers: A Crossover Field Study in Terraced Farmland
Previous Article in Journal
Longitudinal Effects of Physical Inactivity and Obesity on Gait Speed in Older Adults with Frequent Knee Pain: Data from the Osteoarthritis Initiative
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2015, 12(2), 1864-1873; doi:10.3390/ijerph120201864

Parity and Risk of Death from Gallbladder Cancer among a Cohort of Premenopausal Parous Women in Taiwan

1
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan
2
Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, 100 Shih‑Chuan 1st RD, Kaohsiung 807, Taiwan
3
Department of Obstetrics and Gynecology, Kaohsiung Chang-Gung Memorial Hospital, No.123, DA-PI Rd. Niaosng Dist., Kaohsiung 833, Taiwan
4
College of Medicine, Chang-Gung University, No.123, DA-PI Rd. Niaosng Dist., Kaohsiung 833, Taiwan
5
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan
6
Department of Public Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan
7
Division of Environmental Health and Occupational Medicine, National Health Research Institute, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 22 September 2014 / Revised: 4 January 2015 / Accepted: 30 January 2015 / Published: 5 February 2015
View Full-Text   |   Download PDF [748 KB, uploaded 5 February 2015]   |  

Abstract

Little epidemiologic research has been done on the etiology of gallbladder cancer (GC). This cohort study was undertaken to examine whether there is an association between parity and risk of death from GC. The study cohort consisted of 1,292,462 women who had a first and singleton childbirth between 1 January 1978 and 31 December 1987. We tracked each woman from the time of their first childbirth to 31 December 2009, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate the hazard ratios (HR) of death from GC associated with parity. There were 257 GC deaths during 34,980,246 person-years of follow-up. The mortality rate of GC was 0.73 cases per 100,000 person-years. As compared with women who had given birth to only one child, the adjusted HR was 1.20 (95% CI = 0.79–1.83) for women who had two children, 1.47 (95% CI = 0.95–2.29) for women who had three children, and 1.68 (95% CI = 0.99–2.85) for women with four or more births. There was a significant increasing trend in the adjusted HRs for GC with increasing parity. The findings suggested that premenopausal women of higher parity may increase the risk of death from GC. View Full-Text
Keywords: gallbladder cancer; parity; mortality; cohort study; Taiwan gallbladder cancer; parity; mortality; cohort study; Taiwan
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chan, T.-F.; Wu, C.-H.; Chiu, H.-F.; Yang, C.-Y. Parity and Risk of Death from Gallbladder Cancer among a Cohort of Premenopausal Parous Women in Taiwan. Int. J. Environ. Res. Public Health 2015, 12, 1864-1873.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top