Int. J. Environ. Res. Public Health 2014, 11(9), 9345-9360; doi:10.3390/ijerph110909345
Recruitment and Baseline Characteristics of Participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)—A Randomized Controlled Lifestyle Trial†
1
Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland
2
Alzheimer's Disease Research Center, Karolinska Institutet, Novum 5th floor, SE-14157 Stockholm, Sweden
3
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
4
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
5
Aging Research Center, Karolinska Institutet—Stockholm University, Gävlegatan 16, SE-11330 Stockholm, Sweden
6
Institute of Health Sciences/Geriatrics, University of Oulu, and Oulu University Hospital, P.O. Box 5000, FI-90014 University of Oulu, Finland
7
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014 University of Oulu, Finland
8
Oulu City Hospital, Kiviharjuntie 5, FI-90015 Oulu, Finland
9
Department of Neurology, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland
10
Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland
11
Department of Lifestyle and Participation, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland
12
Kuopio Research Institute of Exercise Medicine, Kuopion yliopisto, Haapaniementie 16, 70100 Kuopio, Finland
13
Department of Medicine, Geriatric Clinic, University of Helsinki, and Helsinki University Central Hospital, P.O. Box 22, FI-00014 University of Helsinki, Finland
14
Department of Public Health, University of Helsinki, P.O. Box 40, FI-00014 University of Helsinki, Finland
15
South Ostrobothnia Central Hospital, Huhtalantie 53, FI-60220 Seinäjoki, Finland
16
Center for Vascular Prevention, Danube-University Krems, Dr.-Karl-Dorrek-Str. 30, 3500 Krems, Austria
17
Diabetes Research Group, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia
†
This paper is an extended version of a work presented at the Alzheimer’s Association International Conference, Copenhagen, Denmark, 12–17 July 2014.
*
Author to whom correspondence should be addressed.
Received: 9 July 2014 / Revised: 31 August 2014 / Accepted: 2 September 2014 / Published: 10 September 2014
(This article belongs to the Special Issue Lifestyle Intervention for Chronic Diseases Prevention)
Abstract
Our aim is to describe the study recruitment and baseline characteristics of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) study population. Potential study participants (age 60–77 years, the dementia risk score ≥6) were identified from previous population-based survey cohorts and invited to the screening visit. To be eligible, cognitive performance measured at the screening visit had to be at the mean level or slightly lower than expected for age. Of those invited (n = 5496), 48% (n = 2654) attended the screening visit, and finally 1260 eligible participants were randomized to the intervention and control groups (1:1). The screening visit non-attendees were slightly older, less educated, and had more vascular risk factors and diseases present. The mean (SD) age of the randomized participants was 69.4 (4.7) years, Mini-Mental State Examination 26.7 (2.0) points, systolic blood pressure 140.1 (16.2) mmHg, total serum cholesterol 5.2 (1.0) mmol/L for, and fasting glucose 6.1 (0.9) mmol/L for, with no difference between intervention and control groups. Several modifiable risk factors were present at baseline indicating an opportunity for the intervention. The FINGER study will provide important information on the effect of lifestyle intervention to prevent cognitive impairment among at risk persons. View Full-TextKeywords:
cognitive impairment; dementia; Alzheimer’s disease; lifestyle; intervention; randomized controlled trial
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ngandu, T.; Lehtisalo, J.; Levälahti, E.; Laatikainen, T.; Lindström, J.; Peltonen, M.; Solomon, A.; Ahtiluoto, S.; Antikainen, R.; Hänninen, T.; Jula, A.; Mangialasche, F.; Paajanen, T.; Pajala, S.; Rauramaa, R.; Strandberg, T.; Tuomilehto, J.; Soininen, H.; Kivipelto, M. Recruitment and Baseline Characteristics of Participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)—A Randomized Controlled Lifestyle Trial. Int. J. Environ. Res. Public Health 2014, 11, 9345-9360.
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