Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals
AbstractFood and drinking water are poorly delineated sources of human exposure to chemical food mutagens and endocrine-disrupting chemicals. In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in vitro assays. Commercially processed foods or snacks and various brands of pure water sachets were extracted by solid-phase extraction and liquid-liquid extraction, respectively. Mutagenicity was determined by the conventional Ames test and two complementary assays on two strains of Salmonella (TA 100 and TA 98), while the estrogenic activity was assessed by a yeast bioluminescent assay, using two recombinant yeast strains (Saccharomyces cerevisiae BMAEREluc/ERα and S. cerevisiae BMA64/luc). A third of the food varieties investigated (chin-chin, hamburger, suya and bean cake) were mutagenic in all three assays, either in the presence or absence of S9 mix. Of the packed water samples, five out of the sixteen investigated (31%), were found to be estrogenic, with estradiol and bisphenol A equivalents ranging from 0.79 to 44.0 ng/L and 124.2 to 1,000.8 ng/L, respectively. Hence, although the current situation in Nigeria does not appear to be substantially worse than, e.g., in Europe, regular monitoring is warranted in the future. View Full-Text
- Supplementary File 1:
Supplementary Information (PDF, 138 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Omoruyi, I.M.; Ahamioje, D.; Pohjanvirta, R. Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals. Int. J. Environ. Res. Public Health 2014, 11, 8347-8367.
Omoruyi IM, Ahamioje D, Pohjanvirta R. Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals. International Journal of Environmental Research and Public Health. 2014; 11(8):8347-8367.Chicago/Turabian Style
Omoruyi, Iyekhoetin M.; Ahamioje, Derek; Pohjanvirta, Raimo. 2014. "Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals." Int. J. Environ. Res. Public Health 11, no. 8: 8347-8367.