Int. J. Environ. Res. Public Health 2014, 11(4), 4026-4048; doi:10.3390/ijerph110404026
Article

Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles

1,2,* email, 3email and 4email
Received: 18 February 2014; in revised form: 2 April 2014 / Accepted: 2 April 2014 / Published: 14 April 2014
(This article belongs to the Special Issue Ultrafine Particles and Potential Health Effects)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In order to calculate the dose for nanoparticles (NP), (i) relevant information about the dose metrics and (ii) a proper dose concept are crucial. Since the appropriate metrics for NP toxicity are yet to be elaborated, a general dose calculation model for nanomaterials is not available. Here we propose how to develop a dose assessment model for NP in analogy to the radiation protection dose calculation, introducing the so-called “deposited and the equivalent dose”. As a dose metric we propose the total deposited NP surface area (SA), which has been shown frequently to determine toxicological responses e.g. of lung tissue. The deposited NP dose is proportional to the total surface area of deposited NP per tissue mass, and takes into account primary and agglomerated NP. By using several weighting factors the equivalent dose additionally takes into account various physico-chemical properties of the NP which are influencing the biological responses. These weighting factors consider the specific surface area, the surface textures, the zeta-potential as a measure for surface charge, the particle morphology such as the shape and the length-to-diameter ratio (aspect ratio), the band gap energy levels of metal and metal oxide NP, and the particle dissolution rate. Furthermore, we discuss how these weighting factors influence the equivalent dose of the deposited NP.
Keywords: nanotoxicology; radiation biology; deposited nanoparticle dose; dose rate; equivalent dose; effective dose; nanoparticle surface area
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MDPI and ACS Style

Simkó, M.; Nosske, D.; Kreyling, W.G. Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles. Int. J. Environ. Res. Public Health 2014, 11, 4026-4048.

AMA Style

Simkó M, Nosske D, Kreyling WG. Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles. International Journal of Environmental Research and Public Health. 2014; 11(4):4026-4048.

Chicago/Turabian Style

Simkó, Myrtill; Nosske, Dietmar; Kreyling, Wolfgang G. 2014. "Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles." Int. J. Environ. Res. Public Health 11, no. 4: 4026-4048.


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