Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Environ. Res. Public Health 2014, 11(3), 2764-2779; doi:10.3390/ijerph110302764
Article

Spatial Environmental Modeling of Autoantibody Outcomes among an African American Population

1,* , 1,* , 1
, 1
, 1
, 2
 and 3
Received: 19 December 2013; in revised form: 26 February 2014 / Accepted: 27 February 2014 / Published: 7 March 2014
(This article belongs to the Special Issue Spatial Epidemiology)
View Full-Text   |   Download PDF [474 KB, uploaded 19 June 2014]
Abstract: In this study of autoimmunity among a population of Gullah African Americans in South Carolina, the links between environmental exposures and autoimmunity (presence of antinuclear antibodies (ANA)) have been assessed. The study population included patients with systemic lupus erythematosus (n = 10), their first degree relatives (n = 61), and unrelated controls (n = 9) where 47.5% (n = 38) were ANA positive. This paper presents the methodology used to model ANA status as a function of individual environmental influences, both self-reported and measured, while controlling for known autoimmunity risk factors. We have examined variable dimension reduction and selection methods in our approach. Following the dimension reduction and selection methods, we fit logistic spatial Bayesian models to explore the relationship between our outcome of interest and environmental exposures adjusting for personal variables. Our analysis also includes a validation “strip” where we have interpolated information from a specific geographic area for a subset of the study population that lives in that vicinity. Our results demonstrate that residential proximity to exposure site is important in this form of analysis. The use of a validation strip network demonstrated that even with small sample numbers some significant exposure-outcome relationships can be detected.
Keywords: lupus; autoimmunity; African Americans; environmental metals; soil; groundwater; spatial lupus; autoimmunity; African Americans; environmental metals; soil; groundwater; spatial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Carroll, R.; Lawson, A.B.; Voronca, D.; Rotejanaprasert, C.; Vena, J.E.; Aelion, C.M.; Kamen, D.L. Spatial Environmental Modeling of Autoantibody Outcomes among an African American Population. Int. J. Environ. Res. Public Health 2014, 11, 2764-2779.

AMA Style

Carroll R, Lawson AB, Voronca D, Rotejanaprasert C, Vena JE, Aelion CM, Kamen DL. Spatial Environmental Modeling of Autoantibody Outcomes among an African American Population. International Journal of Environmental Research and Public Health. 2014; 11(3):2764-2779.

Chicago/Turabian Style

Carroll, Rachel; Lawson, Andrew B.; Voronca, Delia; Rotejanaprasert, Chawarat; Vena, John E.; Aelion, Claire M.; Kamen, Diane L. 2014. "Spatial Environmental Modeling of Autoantibody Outcomes among an African American Population." Int. J. Environ. Res. Public Health 11, no. 3: 2764-2779.


Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert