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Mar. Drugs 2011, 9(7), 1243-1253; doi:10.3390/md9071243
Article

Cembranoids with 3,14-Ether Linkage and a Secocembrane with Bistetrahydrofuran from the Dongsha Atoll Soft Coral Lobophytum sp.

1
,
2,3
,
2,3
 and
1,4,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 21 June 2011 / Accepted: 5 July 2011 / Published: 12 July 2011
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Abstract

Four new cembranoids, lobophylins A–D (14), and one novel secocembrane, lobophylin E (5) were isolated from a soft coral Lobophytum sp. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods. Among these metabolites, 14 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 3,14-ether linkage. In addition, 5 is the first secocembrane possessing two tetrahydrofuran moieties with 3,14- and 4,7-ether linkages.
Keywords: soft coral; secocembrane; Lobophytum; tetrahydrofuran soft coral; secocembrane; Lobophytum; tetrahydrofuran
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hegazy, M.E.F.; Su, J.-H.; Sung, P.-J.; Sheu, J.-H. Cembranoids with 3,14-Ether Linkage and a Secocembrane with Bistetrahydrofuran from the Dongsha Atoll Soft Coral Lobophytum sp.. Mar. Drugs 2011, 9, 1243-1253.

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