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Mar. Drugs 2011, 9(7), 1243-1253; https://doi.org/10.3390/md9071243

Cembranoids with 3,14-Ether Linkage and a Secocembrane with Bistetrahydrofuran from the Dongsha Atoll Soft Coral Lobophytum sp.

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
4
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
*
Author to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 21 June 2011 / Accepted: 5 July 2011 / Published: 12 July 2011
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Abstract

Four new cembranoids, lobophylins A–D (14), and one novel secocembrane, lobophylin E (5) were isolated from a soft coral Lobophytum sp. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods. Among these metabolites, 14 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 3,14-ether linkage. In addition, 5 is the first secocembrane possessing two tetrahydrofuran moieties with 3,14- and 4,7-ether linkages. View Full-Text
Keywords: soft coral; secocembrane; Lobophytum; tetrahydrofuran soft coral; secocembrane; Lobophytum; tetrahydrofuran
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Hegazy, M.E.F.; Su, J.-H.; Sung, P.-J.; Sheu, J.-H. Cembranoids with 3,14-Ether Linkage and a Secocembrane with Bistetrahydrofuran from the Dongsha Atoll Soft Coral Lobophytum sp.. Mar. Drugs 2011, 9, 1243-1253.

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