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Mar. Drugs 2011, 9(7), 1210-1219; doi:10.3390/md9071210
Article

A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

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Received: 23 May 2011; in revised form: 16 June 2011 / Accepted: 23 June 2011 / Published: 7 July 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract: Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
Keywords: ponges; Sarcotragus spinosulus; marine natural products; hydroxylated polyprenylhydroquinone; bioactivity ponges; Sarcotragus spinosulus; marine natural products; hydroxylated polyprenylhydroquinone; bioactivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Abed, C.; Legrave, N.; Dufies, M.; Robert, G.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus. Mar. Drugs 2011, 9, 1210-1219.

AMA Style

Abed C, Legrave N, Dufies M, Robert G, Guérineau V, Vacelet J, Auberger P, Amade P, Mehiri M. A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus. Marine Drugs. 2011; 9(7):1210-1219.

Chicago/Turabian Style

Abed, Charline; Legrave, Nathalie; Dufies, Maeva; Robert, Guillaume; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed. 2011. "A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus." Mar. Drugs 9, no. 7: 1210-1219.



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