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A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France
Marseille Oceanology Center, University of Aix-Marseille, CNRS UMR 6540 DIMAR, Endoume Marine Station, Batterie des Lions Street, 13007 Marseille, France
INSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 23 May 2011; in revised form: 16 June 2011 / Accepted: 23 June 2011 / Published: 7 July 2011
Abstract: Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
Keywords: ponges; Sarcotragus spinosulus; marine natural products; hydroxylated polyprenylhydroquinone; bioactivity
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Abed, C.; Legrave, N.; Dufies, M.; Robert, G.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus. Mar. Drugs 2011, 9, 1210-1219.
Abed C, Legrave N, Dufies M, Robert G, Guérineau V, Vacelet J, Auberger P, Amade P, Mehiri M. A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus. Marine Drugs. 2011; 9(7):1210-1219.
Abed, Charline; Legrave, Nathalie; Dufies, Maeva; Robert, Guillaume; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed. 2011. "A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus." Mar. Drugs 9, no. 7: 1210-1219.