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Mar. Drugs 2011, 9(7), 1210-1219; doi:10.3390/md9071210
Article

A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

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1 Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France 2 Marseille Oceanology Center, University of Aix-Marseille, CNRS UMR 6540 DIMAR, Endoume Marine Station, Batterie des Lions Street, 13007 Marseille, France 3 INSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France 4 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 16 June 2011 / Accepted: 23 June 2011 / Published: 7 July 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
Keywords: ponges; Sarcotragus spinosulus; marine natural products; hydroxylated polyprenylhydroquinone; bioactivity ponges; Sarcotragus spinosulus; marine natural products; hydroxylated polyprenylhydroquinone; bioactivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abed, C.; Legrave, N.; Dufies, M.; Robert, G.; Guérineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus. Mar. Drugs 2011, 9, 1210-1219.

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