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Mar. Drugs 2011, 9(7), 1187-1209; doi:10.3390/md9071187

Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)

1
Laboratoire de Biotechnologie et Chimie Marines (LBCM), Centre de recherche Yves Coppens, Université européenne de Bretagne (UEB), Université de Bretagne-Sud. Vannes, France
2
Laboratoire de Diversité et Conservation de Systèmes Biologiques (LDICOSYB), Faculté de Science, Université Abdelmalek Essaâdi, Tétouan, Maroc. B.P. 2121, 93003, Morocco
3
URRMA R&D, Centre de vie agora, bâtiment C, B.P. 1055, Z.I. des paluds, 13781 Aubagne Cedex, France
4
Laboratoire Biotechnologies et Molécules Marines, IFREMER, B.P. 21105 44311 Nantes, France
5
Université européenne de Bretagne, Université de Bretagne Occidentale, Service Commun de Résonance Magnétique Nucléaire, UFR Sciences et Techniques, Avenue Le Gorgeu, CS 93837 29238 Brest Cedex 3, France
*
Authors to whom correspondence should be addressed.
Received: 9 March 2011 / Revised: 25 May 2011 / Accepted: 9 June 2011 / Published: 6 July 2011
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Abstract

Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 µg/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC50 of 4.1 and 17.2 µg/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively.
Keywords: Herpes simplex virus; human immunodeficiency virus; antiviral activity; sulfated polysaccharide; S. coronopifolius; B. thuyoides; chemical composition Herpes simplex virus; human immunodeficiency virus; antiviral activity; sulfated polysaccharide; S. coronopifolius; B. thuyoides; chemical composition
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MDPI and ACS Style

Bouhlal, R.; Haslin, C.; Chermann, J.-C.; Colliec-Jouault, S.; Sinquin, C.; Simon, G.; Cerantola, S.; Riadi, H.; Bourgougnon, N. Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales). Mar. Drugs 2011, 9, 1187-1209.

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