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Mar. Drugs 2011, 9(6), 994-1006; doi:10.3390/md9060994
Article

Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

1
,
1
,
2,3
,
1
,
4
,
5
 and
1,6,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 6 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 April 2011 / Revised: 26 May 2011 / Accepted: 30 May 2011 / Published: 9 June 2011
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Abstract

Seven new cembranoids, sarcocrassocolides F–L (17), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure–activity relationship was studied. Compounds 17 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, W.-Y.; Lu, Y.; Su, J.-H.; Wen, Z.-H.; Dai, C.-F.; Kuo, Y.-H.; Sheu, J.-H. Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2011, 9, 994-1006.

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