Mar. Drugs 2011, 9(6), 994-1006; doi:10.3390/md9060994
Article

Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 6 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 April 2011; in revised form: 26 May 2011 / Accepted: 30 May 2011 / Published: 9 June 2011
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Abstract: Seven new cembranoids, sarcocrassocolides F–L (17), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure–activity relationship was studied. Compounds 17 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity

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MDPI and ACS Style

Lin, W.-Y.; Lu, Y.; Su, J.-H.; Wen, Z.-H.; Dai, C.-F.; Kuo, Y.-H.; Sheu, J.-H. Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2011, 9, 994-1006.

AMA Style

Lin W-Y, Lu Y, Su J-H, Wen Z-H, Dai C-F, Kuo Y-H, Sheu J-H. Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Marine Drugs. 2011; 9(6):994-1006.

Chicago/Turabian Style

Lin, Wan-Yu; Lu, Yi; Su, Jui-Hsin; Wen, Zhi-Hong; Dai, Chang-Feng; Kuo, Yao-Haur; Sheu, Jyh-Horng. 2011. "Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule." Mar. Drugs 9, no. 6: 994-1006.

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