Mar. Drugs 2011, 9(6), 994-1006; doi:10.3390/md9060994
Article

Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

1email, 1email, 2,3email, 1email, 4email, 5email and 1,6,* email
Received: 25 April 2011; in revised form: 26 May 2011 / Accepted: 30 May 2011 / Published: 9 June 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Seven new cembranoids, sarcocrassocolides F–L (17), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure–activity relationship was studied. Compounds 17 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
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MDPI and ACS Style

Lin, W.-Y.; Lu, Y.; Su, J.-H.; Wen, Z.-H.; Dai, C.-F.; Kuo, Y.-H.; Sheu, J.-H. Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2011, 9, 994-1006.

AMA Style

Lin W-Y, Lu Y, Su J-H, Wen Z-H, Dai C-F, Kuo Y-H, Sheu J-H. Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Marine Drugs. 2011; 9(6):994-1006.

Chicago/Turabian Style

Lin, Wan-Yu; Lu, Yi; Su, Jui-Hsin; Wen, Zhi-Hong; Dai, Chang-Feng; Kuo, Yao-Haur; Sheu, Jyh-Horng. 2011. "Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule." Mar. Drugs 9, no. 6: 994-1006.

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