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Mar. Drugs 2011, 9(3), 294-306; doi:10.3390/md9030294
Article

Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

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Received: 13 January 2011; in revised form: 11 February 2011 / Accepted: 24 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract: In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 µg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 µg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
Keywords: Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tarman, K.; Lindequist, U.; Wende, K.; Porzel, A.; Arnold, N.; Wessjohann, L.A. Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats. Mar. Drugs 2011, 9, 294-306.

AMA Style

Tarman K, Lindequist U, Wende K, Porzel A, Arnold N, Wessjohann LA. Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats. Marine Drugs. 2011; 9(3):294-306.

Chicago/Turabian Style

Tarman, Kustiariyah; Lindequist, Ulrike; Wende, Kristian; Porzel, Andrea; Arnold, Norbert; Wessjohann, Ludger A. 2011. "Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats." Mar. Drugs 9, no. 3: 294-306.


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