Mar. Drugs 2011, 9(3), 294-306; doi:10.3390/md9030294
Article

Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

1 Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany 2 Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Jl. Agathis 1, 16680 Darmaga-Bogor, Indonesia 3 Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany
* Author to whom correspondence should be addressed.
Received: 13 January 2011; in revised form: 11 February 2011 / Accepted: 24 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract: In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 µg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 µg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
Keywords: Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds

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MDPI and ACS Style

Tarman, K.; Lindequist, U.; Wende, K.; Porzel, A.; Arnold, N.; Wessjohann, L.A. Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats. Mar. Drugs 2011, 9, 294-306.

AMA Style

Tarman K, Lindequist U, Wende K, Porzel A, Arnold N, Wessjohann LA. Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats. Marine Drugs. 2011; 9(3):294-306.

Chicago/Turabian Style

Tarman, Kustiariyah; Lindequist, Ulrike; Wende, Kristian; Porzel, Andrea; Arnold, Norbert; Wessjohann, Ludger A. 2011. "Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats." Mar. Drugs 9, no. 3: 294-306.

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