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Kinase Inhibitors from Marine Sponges
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
Centre for Medicinal Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
* Author to whom correspondence should be addressed.
Received: 6 September 2011; in revised form: 1 October 2011 / Accepted: 14 October 2011 / Published: 24 October 2011
Abstract: Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
Keywords: marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents
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Cite This Article
MDPI and ACS Style
Skropeta, D.; Pastro, N.; Zivanovic, A. Kinase Inhibitors from Marine Sponges. Mar. Drugs 2011, 9, 2131-2154.
Skropeta D, Pastro N, Zivanovic A. Kinase Inhibitors from Marine Sponges. Marine Drugs. 2011; 9(10):2131-2154.
Skropeta, Danielle; Pastro, Natalie; Zivanovic, Ana. 2011. "Kinase Inhibitors from Marine Sponges." Mar. Drugs 9, no. 10: 2131-2154.