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Mar. Drugs 2011, 9(10), 2131-2154; doi:10.3390/md9102131
Review

Kinase Inhibitors from Marine Sponges

1,2,* , 1
 and
1
Received: 6 September 2011 / Revised: 1 October 2011 / Accepted: 14 October 2011 / Published: 24 October 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract

Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
Keywords: marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Skropeta, D.; Pastro, N.; Zivanovic, A. Kinase Inhibitors from Marine Sponges. Mar. Drugs 2011, 9, 2131-2154.

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