Mar. Drugs 2011, 9(10), 2131-2154; doi:10.3390/md9102131
Review

Kinase Inhibitors from Marine Sponges

Danielle Skropeta 1,2,* email, Natalie Pastro 1 email and Ana Zivanovic 1 email
1 School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia 2 Centre for Medicinal Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
* Author to whom correspondence should be addressed.
Received: 6 September 2011; in revised form: 1 October 2011 / Accepted: 14 October 2011 / Published: 24 October 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
PDF Full-text Download PDF Full-Text [537 KB, uploaded 24 October 2011 16:04 CEST]
Abstract: Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
Keywords: marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Skropeta, D.; Pastro, N.; Zivanovic, A. Kinase Inhibitors from Marine Sponges. Mar. Drugs 2011, 9, 2131-2154.

AMA Style

Skropeta D, Pastro N, Zivanovic A. Kinase Inhibitors from Marine Sponges. Marine Drugs. 2011; 9(10):2131-2154.

Chicago/Turabian Style

Skropeta, Danielle; Pastro, Natalie; Zivanovic, Ana. 2011. "Kinase Inhibitors from Marine Sponges." Mar. Drugs 9, no. 10: 2131-2154.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert