Kinase Inhibitors from Marine Sponges
AbstractProtein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
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Skropeta, D.; Pastro, N.; Zivanovic, A. Kinase Inhibitors from Marine Sponges. Mar. Drugs 2011, 9, 2131-2154.
Skropeta D, Pastro N, Zivanovic A. Kinase Inhibitors from Marine Sponges. Marine Drugs. 2011; 9(10):2131-2154.Chicago/Turabian Style
Skropeta, Danielle; Pastro, Natalie; Zivanovic, Ana. 2011. "Kinase Inhibitors from Marine Sponges." Mar. Drugs 9, no. 10: 2131-2154.