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New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals
Laboratoire de Chimie des Biomolécules et de l'Environnement, Centre de Phytopharmacie, Université de Perpignan, 52 avenue Paul Alduy, 66860 Perpignan Cedex, France
Department of Chemistry, University of Mauritius, Réduit, Mauritius
Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, 15, Faculté des Sciences et Technologies, Université de La Réunion, avenue René Cassin-BP 7151, 97715 Saint Denis, Messag., Cedex 9, France
* Author to whom correspondence should be addressed.
Received: 25 January 2010; in revised form: 8 February 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
Abstract: Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1–3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
Keywords: lobane; cembrane; acetylcholinesterase inhibitors; Sarcophyton; Lobophytum
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Bonnard, I.; Jhaumeer-Laulloo, S.B.; Bontemps, N.; Banaigs, B.; Aknin, M. New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals. Mar. Drugs 2010, 8, 359-372.
Bonnard I, Jhaumeer-Laulloo SB, Bontemps N, Banaigs B, Aknin M. New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals. Marine Drugs. 2010; 8(2):359-372.
Bonnard, Isabelle; Jhaumeer-Laulloo, Sabina B.; Bontemps, Nataly; Banaigs, Bernard; Aknin, Maurice. 2010. "New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals." Mar. Drugs 8, no. 2: 359-372.