Mar. Drugs 2010, 8(2), 359-372; doi:10.3390/md8020359

New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals

1,* email, 2email, 1, 1 and 3email
Received: 25 January 2010; in revised form: 8 February 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 13 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
Keywords: lobane; cembrane; acetylcholinesterase inhibitors; Sarcophyton; Lobophytum
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MDPI and ACS Style

Bonnard, I.; Jhaumeer-Laulloo, S.B.; Bontemps, N.; Banaigs, B.; Aknin, M. New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals. Mar. Drugs 2010, 8, 359-372.

AMA Style

Bonnard I, Jhaumeer-Laulloo SB, Bontemps N, Banaigs B, Aknin M. New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals. Marine Drugs. 2010; 8(2):359-372.

Chicago/Turabian Style

Bonnard, Isabelle; Jhaumeer-Laulloo, Sabina B.; Bontemps, Nataly; Banaigs, Bernard; Aknin, Maurice. 2010. "New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals." Mar. Drugs 8, no. 2: 359-372.

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