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Mar. Drugs 2010, 8(2), 359-372; doi:10.3390/md8020359
Article

New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals

1,* , 2
, 1, 1 and 3
1 Laboratoire de Chimie des Biomolécules et de l'Environnement, Centre de Phytopharmacie, Université de Perpignan, 52 avenue Paul Alduy, 66860 Perpignan Cedex, France 2 Department of Chemistry, University of Mauritius, Réduit, Mauritius 3 Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, 15, Faculté des Sciences et Technologies, Université de La Réunion, avenue René Cassin-BP 7151, 97715 Saint Denis, Messag., Cedex 9, France
* Author to whom correspondence should be addressed.
Received: 25 January 2010 / Revised: 8 February 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
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Abstract

Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 13 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
Keywords: lobane; cembrane; acetylcholinesterase inhibitors; Sarcophyton; Lobophytum lobane; cembrane; acetylcholinesterase inhibitors; Sarcophyton; Lobophytum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bonnard, I.; Jhaumeer-Laulloo, S.B.; Bontemps, N.; Banaigs, B.; Aknin, M. New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals. Mar. Drugs 2010, 8, 359-372.

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