Mar. Drugs 2010, 8(12), 2961-2975; doi:10.3390/md8122961

Sterols from the Madagascar Sponge Fascaplysinopsis sp.

1email, 1email, 2email, 3email and 1,* email
Received: 21 October 2010; in revised form: 13 December 2010 / Accepted: 16 December 2010 / Published: 17 December 2010
(This article belongs to the Special Issue Marine Lipids)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The sponge Fascaplysinopsis sp. (order Dictyoceratida, Family Thorectidae) from the west coast of Madagascar (Indian Ocean) is a particularly rich source of bioactive nitrogenous macrolides. The previous studies on this organism led to the suggestion that the latter should originate from associated microsymbionts. In order to evaluate the influence of microsymbionts on lipid content, 10 samples of Fascaplysinopsis sp. were investigated for their sterol composition. Contrary to the secondary metabolites, the sterol patterns established were qualitatively and quantitatively stable: 14 sterols with different unsaturated nuclei, D5, D7 and D5,7, were identified; the last ones being the main sterols of the investigated sponges. The chemotaxonomic significance of these results for the order Dictyoceratida is also discussed in the context of the literature. The conjugated diene system in D5,7 sterols is known to be unstable and easily photo-oxidized during storage and/or experiments to produce 5a,8a-epidioxy sterols. However, in this study, no 5a,8a-epidioxysterols (or only trace amounts) were observed. Thus, it was supposed that photo-oxidation was avoided thanks to the natural antioxidants detected in Fascaplysinopsis sp. by both the DPPH and b-caroten bleaching assays.
Keywords: Fascaplysinopsis sp.; Dictyoceratida; D5,7-sterols; sponge-associated microorganisms; chemotaxonomy
PDF Full-text Download PDF Full-Text [357 KB, uploaded 17 December 2010 17:49 CET]

Export to BibTeX |

MDPI and ACS Style

Aknin, M.; Gros, E.; Vacelet, J.; Kashman, Y.; Gauvin-Bialecki, A. Sterols from the Madagascar Sponge Fascaplysinopsis sp.. Mar. Drugs 2010, 8, 2961-2975.

AMA Style

Aknin M, Gros E, Vacelet J, Kashman Y, Gauvin-Bialecki A. Sterols from the Madagascar Sponge Fascaplysinopsis sp.. Marine Drugs. 2010; 8(12):2961-2975.

Chicago/Turabian Style

Aknin, Maurice; Gros, Emmanuelle; Vacelet, Jean; Kashman, Yoel; Gauvin-Bialecki, Anne. 2010. "Sterols from the Madagascar Sponge Fascaplysinopsis sp.." Mar. Drugs 8, no. 12: 2961-2975.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert