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Mar. Drugs 2009, 7(4), 833-849; doi:10.3390/md7040833
Review

Terpenyl-Purines from the Sea

Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Received: 12 November 2009 / Revised: 26 November 2009 / Accepted: 22 December 2009 / Published: 23 December 2009
(This article belongs to the Special Issue Alkaloid Analogs)
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Abstract

Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.
Keywords: agelasine; agelasimine; ageline; asmarine; alkyl-purine; terpene-purine; terpenylpurine agelasine; agelasimine; ageline; asmarine; alkyl-purine; terpene-purine; terpenylpurine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gordaliza, M. Terpenyl-Purines from the Sea. Mar. Drugs 2009, 7, 833-849.

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