Terpenyl-Purines from the Sea
AbstractAgelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Gordaliza, M. Terpenyl-Purines from the Sea. Mar. Drugs 2009, 7, 833-849.
Gordaliza M. Terpenyl-Purines from the Sea. Marine Drugs. 2009; 7(4):833-849.Chicago/Turabian Style
Gordaliza, Marina. 2009. "Terpenyl-Purines from the Sea." Mar. Drugs 7, no. 4: 833-849.