Mar. Drugs 2009, 7(4), 833-849; doi:10.3390/md7040833
Review

Terpenyl-Purines from the Sea

Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Received: 12 November 2009; in revised form: 26 November 2009 / Accepted: 22 December 2009 / Published: 23 December 2009
(This article belongs to the Special Issue Alkaloid Analogs)
PDF Full-text Download PDF Full-Text [175 KB, uploaded 23 December 2009 11:23 CET]
Abstract: Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.
Keywords: agelasine; agelasimine; ageline; asmarine; alkyl-purine; terpene-purine; terpenylpurine

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Gordaliza, M. Terpenyl-Purines from the Sea. Mar. Drugs 2009, 7, 833-849.

AMA Style

Gordaliza M. Terpenyl-Purines from the Sea. Marine Drugs. 2009; 7(4):833-849.

Chicago/Turabian Style

Gordaliza, Marina. 2009. "Terpenyl-Purines from the Sea." Mar. Drugs 7, no. 4: 833-849.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert