Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

doi:10.3390/md7040816

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Mar. Drugs 2009, 7(4), 816-832; doi:10.3390/md7040816

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Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi^1,2, Palupi Margiastuti¹, Toshiaki Teruya³, Junsei Taira⁴, Kiyotake Suenaga⁵ and Katsuhiro Ueda^1,*

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Received: 19 November 2009; in revised form: 14 December 2009 / Accepted: 16 December 2009 / Published: 17 December 2009

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract: A series of new C₁₁ cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

Keywords: Lissoclinum; Diplosoma; cyclopentenone; didemnenone; cytotoxicity

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MDPI and ACS Style

Ogi, T.; Margiastuti, P.; Teruya, T.; Taira, J.; Suenaga, K.; Ueda, K. Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Mar. Drugs 2009, 7, 816-832.

AMA Style

Ogi T, Margiastuti P, Teruya T, Taira J, Suenaga K, Ueda K. Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Marine Drugs. 2009; 7(4):816-832.

Chicago/Turabian Style

Ogi, Takayuki; Margiastuti, Palupi; Teruya, Toshiaki; Taira, Junsei; Suenaga, Kiyotake; Ueda, Katsuhiro. 2009. "Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.." Mar. Drugs 7, no. 4: 816-832.

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