Mar. Drugs 2009, 7(4), 816-832; doi:10.3390/md7040816
Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.
1
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
2
Okinawa Industrial Technology Center, 12-2 Suzaki, Uruma, Okinawa 904-2234, Japan
3
Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
4
Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago, Okinawa 905-2192, Japan
5
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
*
Author to whom correspondence should be addressed.
Received: 19 November 2009 / Revised: 14 December 2009 / Accepted: 16 December 2009 / Published: 17 December 2009
Abstract
A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).Keywords:
Lissoclinum; Diplosoma; cyclopentenone; didemnenone; cytotoxicity
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Ogi, T.; Margiastuti, P.; Teruya, T.; Taira, J.; Suenaga, K.; Ueda, K. Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Mar. Drugs 2009, 7, 816-832.
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