Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

doi:10.3390/md7040816

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Mar. Drugs 2009, 7(4), 816-832; doi:10.3390/md7040816

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Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi^1,2, Palupi Margiastuti¹, Toshiaki Teruya³, Junsei Taira⁴, Kiyotake Suenaga⁵ and Katsuhiro Ueda^1,*

¹ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan ² Okinawa Industrial Technology Center, 12-2 Suzaki, Uruma, Okinawa 904-2234, Japan ³ Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan ⁴ Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago, Okinawa 905-2192, Japan ⁵ Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan

* Author to whom correspondence should be addressed.

Received: 19 November 2009; in revised form: 14 December 2009 / Accepted: 16 December 2009 / Published: 17 December 2009

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Abstract: A series of new C₁₁ cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

Keywords: Lissoclinum; Diplosoma; cyclopentenone; didemnenone; cytotoxicity

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MDPI and ACS Style

Ogi, T.; Margiastuti, P.; Teruya, T.; Taira, J.; Suenaga, K.; Ueda, K. Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Mar. Drugs 2009, 7, 816-832.

AMA Style

Ogi T, Margiastuti P, Teruya T, Taira J, Suenaga K, Ueda K. Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Marine Drugs. 2009; 7(4):816-832.

Chicago/Turabian Style

Ogi, Takayuki; Margiastuti, Palupi; Teruya, Toshiaki; Taira, Junsei; Suenaga, Kiyotake; Ueda, Katsuhiro. 2009. "Isolation of C₁₁ Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.." Mar. Drugs 7, no. 4: 816-832.

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