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Mar. Drugs 2009, 7(4), 816-832; doi:10.3390/md7040816
Article

Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

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Received: 19 November 2009 / Revised: 14 December 2009 / Accepted: 16 December 2009 / Published: 17 December 2009
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Abstract

A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).
Keywords: Lissoclinum; Diplosoma; cyclopentenone; didemnenone; cytotoxicity Lissoclinum; Diplosoma; cyclopentenone; didemnenone; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ogi, T.; Margiastuti, P.; Teruya, T.; Taira, J.; Suenaga, K.; Ueda, K. Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.. Mar. Drugs 2009, 7, 816-832.

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