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Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum
Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan
National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 26 August 2009; in revised form: 19 September 2009 / Accepted: 23 September 2009 / Published: 23 September 2009
Abstract: Two new briarane-related diterpenoids, designated as excavatoids E (1) andF (2), were isolated from the cultured octocoral Briareum excavatum. The structures ofcompounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.
Keywords: excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil
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Sung, P.-J.; Chen, B.-Y.; Lin, M.-R.; Hwang, T.-L.; Wang, W.-H.; Sheu, J.-H.; Wu, Y.-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Mar. Drugs 2009, 7, 472-482.
Sung P-J, Chen B-Y, Lin M-R, Hwang T-L, Wang W-H, Sheu J-H, Wu Y-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Marine Drugs. 2009; 7(3):472-482.
Sung, Ping-Jyun; Chen, Bo-Yuan; Lin, Mei-Ru; Hwang, Tsong-Long; Wang, Wei-Hsien; Sheu, Jyh-Horng; Wu, Yang-Chang. 2009. "Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum." Mar. Drugs 7, no. 3: 472-482.