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Mar. Drugs 2009, 7(3), 472-482; doi:10.3390/md7030472
Article

Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

1,2,3,* , 1,2
,
2,3
,
4
,
2,3
,
3
 and
5,*
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan 2 National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 26 August 2009 / Revised: 19 September 2009 / Accepted: 23 September 2009 / Published: 23 September 2009
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Abstract

Two new briarane-related diterpenoids, designated as excavatoids E (1) andF (2), were isolated from the cultured octocoral Briareum excavatum. The structures ofcompounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.
Keywords: excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sung, P.-J.; Chen, B.-Y.; Lin, M.-R.; Hwang, T.-L.; Wang, W.-H.; Sheu, J.-H.; Wu, Y.-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Mar. Drugs 2009, 7, 472-482.

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