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Mar. Drugs 2009, 7(3), 472-482; doi:10.3390/md7030472
Article

Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

1,2,3,* , 1,2
, 2,3
, 4
, 2,3
, 3
 and 5,*
1 Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan 2 National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 26 August 2009 / Revised: 19 September 2009 / Accepted: 23 September 2009 / Published: 23 September 2009
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Abstract

Two new briarane-related diterpenoids, designated as excavatoids E (1) andF (2), were isolated from the cultured octocoral Briareum excavatum. The structures ofcompounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.
Keywords: excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sung, P.-J.; Chen, B.-Y.; Lin, M.-R.; Hwang, T.-L.; Wang, W.-H.; Sheu, J.-H.; Wu, Y.-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Mar. Drugs 2009, 7, 472-482.

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