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Antibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa
Bioorganic Chemistry, Chemical Oceanography Division, National Institute of Oceanography, Council of Scientific and Industrial Research (CSIR), Dona Paula, 403 004, Goa, India
Dept. of Natural Products, Piramal Life Sciences Limited, Nirlon Complex, Goregaon, Mumbai, 400 063, India
Dept. of Chemistry, Goa University, Taleigao, 403 206, Goa, India
* Author to whom correspondence should be addressed.
Received: 1 July 2009; in revised form: 1 September 2009 / Accepted: 21 September 2009 / Published: 22 September 2009
Abstract: 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol isolated from the marine sponge Dysidea granulosa (Bergquist) collected off the coast of Lakshadweep islands, Indian Ocean, exhibited potent and broad spectrum in-vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), vancomycin resistant Enterococci (VRE), vancomycin sensitive Enterococci (VSE) and Bacillus spp. Minimal inhibitory concentration (MIC) was evaluated against 57 clinical and standard strains of Gram positive and Gram negative bacteria. The observed MIC range was 0.117-2.5 μg/mL against all the Gram positive bacteria and 0.5-2 μg/mL against Gram negative bacteria. The in-vitro antibacterial activity observed was better than that of the standard antibiotic linezolid, a marketed anti-MRSA drug. The results establish 2-(2’,4’-dibromophenoxy)-4,6-dibromophenol, as a potential lead molecule for anti-MRSA and anti-VRE drug development.
Keywords: Dysidea granulosa; 2-(2’,4’-dibromophenoxy)-4,6-dibromophenol; antibacterial activity; methicillin resistant Staphylococcus aureus; vancomycin resistant enterococci
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Shridhar, D.M.P.; Mahajan, G.B.; Kamat, V.P.; Naik, C.G.; Parab, R.R.; Thakur, N.R.; Mishra, P.D. Antibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa. Mar. Drugs 2009, 7, 464-471.
Shridhar DMP, Mahajan GB, Kamat VP, Naik CG, Parab RR, Thakur NR, Mishra PD. Antibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa. Marine Drugs. 2009; 7(3):464-471.
Shridhar, Divya M. P.; Mahajan, Girish B.; Kamat, Vijayendra P.; Naik, Chandrakant G.; Parab, Rajashri R.; Thakur, Nidhi R.; Mishra, Prabhu D. 2009. "Antibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa." Mar. Drugs 7, no. 3: 464-471.