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Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
Department of Pharmacognocy and Pharmaceutical Botany, Center for Bioactive Natural Products from Marine Organisms and Endophytic Fungi (BNPME), Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
Tsukuba Research Laboratories, Eisai Co. Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan
* Authors to whom correspondence should be addressed.
Received: 26 August 2009; in revised form: 14 October 2009 / Accepted: 19 October 2009 / Published: 19 October 2009
Abstract: Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC50 values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products.
Keywords: renieramycin M; jorunnamycin C; marine sponge; oligonucleotide microarray; antitumor agent
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Charupant, K.; Suwanborirux, K.; Daikuhara, N.; Yokoya, M.; Ushijima-Sugano, R.; Kawai, T.; Owa, T.; Saito, N. Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms. Mar. Drugs 2009, 7, 483-494.
Charupant K, Suwanborirux K, Daikuhara N, Yokoya M, Ushijima-Sugano R, Kawai T, Owa T, Saito N. Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms. Marine Drugs. 2009; 7(4):483-494.
Charupant, Kornvika; Suwanborirux, Khanit; Daikuhara, Naomi; Yokoya, Masashi; Ushijima-Sugano, Rie; Kawai, Takatoshi; Owa, Takashi; Saito, Naoki. 2009. "Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms." Mar. Drugs 7, no. 4: 483-494.