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Open AccessCommunication
Mar. Drugs 2009, 7(4), 483-494; doi:10.3390/md7040483

Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms

1
Department of Pharmacognocy and Pharmaceutical Botany, Center for Bioactive Natural Products from Marine Organisms and Endophytic Fungi (BNPME), Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
2
Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
3
Tsukuba Research Laboratories, Eisai Co. Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan
*
Authors to whom correspondence should be addressed.
Received: 26 August 2009 / Revised: 14 October 2009 / Accepted: 19 October 2009 / Published: 19 October 2009
(This article belongs to the Special Issue Marine Actinomycetes: A New Source of Natural Products)
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Abstract

Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC50 values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products.
Keywords: renieramycin M; jorunnamycin C; marine sponge; oligonucleotide microarray; antitumor agent renieramycin M; jorunnamycin C; marine sponge; oligonucleotide microarray; antitumor agent
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Charupant, K.; Suwanborirux, K.; Daikuhara, N.; Yokoya, M.; Ushijima-Sugano, R.; Kawai, T.; Owa, T.; Saito, N. Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms. Mar. Drugs 2009, 7, 483-494.

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