A correction was published on 21 October 2009, see Mar. Drugs 2009, 7(4), 495-496.

Mar. Drugs 2009, 7(1), 24-44; doi:10.3390/md7010024
Article

Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China

1,* email, 2email, 1email, 3email, 1, 1email, 2email, 2email, 3email, 4email and 1, 5email
Received: 11 December 2008; in revised form: 12 January 2009 / Accepted: 21 January 2009 / Published: 3 January 2009
(This article belongs to the Special Issue Marine Drugs Studies in China)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 actinomycetes were isolated and of these approximately 20%, 5%, and 10% inhibited the growth of Human Colon Tumor 116 cells, Candida albicans and Staphylococcus aureus, respectively, while 3% inhibited protein tyrosine phosphatase 1B (PTP1B), a protein related to diabetes. In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. Representative bioactive isolates were characterized using genotypic and phenotypic procedures and classified to thirteen genera, notably to the genera Micromonospora and Streptomyces. Actinomycetes showing cytotoxic activity were assigned to seven genera whereas only Micromonospora and Streptomyces strains showed anti-PTP1B activity. We conclude that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes.
Keywords: Mangroves; actinomycete diversity; marine drug discovery; high-throughput screening; growth inhibition; protein tyrosine phosphatase 1B; aurora kinase A; caspase
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MDPI and ACS Style

Hong, K.; Gao, A.-H.; Xie, Q.-Y.; Gao, H.G.; Zhuang, L.; Lin, H.-P.; Yu, H.-P.; Li, J.; Yao, X.-S.; Goodfellow, M.; Ruan, J.-S. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Mar. Drugs 2009, 7, 24-44.

AMA Style

Hong K, Gao A-H, Xie Q-Y, Gao HG, Zhuang L, Lin H-P, Yu H-P, Li J, Yao X-S, Goodfellow M, Ruan J-S. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Marine Drugs. 2009; 7(1):24-44.

Chicago/Turabian Style

Hong, Kui; Gao, An-Hui; Xie, Qing-Yi; Gao, Hao Gao; Zhuang, Ling; Lin, Hai-Peng; Yu, Hai-Ping; Li, Jia; Yao, Xin-Sheng; Goodfellow, Michael; Ruan, Ji-Sheng. 2009. "Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China." Mar. Drugs 7, no. 1: 24-44.

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