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Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine
Modern Biochemistry Center, Guangdong Ocean University, Zhanjiang 524088, P.R.China
College of Food Science & Technology, Guangdong Ocean University, Zhanjiang 524088, P.R.China
Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, P.R. China
* Author to whom correspondence should be addressed.
Received: 19 September 2008; in revised form: 29 October 2008 / Accepted: 11 December 2008 / Published: 14 January 2009
Abstract: To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females in each group. At the end of the experiment, animals were sacrificed to investigate organ indexes and antioxidant ability of the spleen, peripheral blood profile and quantities of bone marrow nucleated cells. Results showed that the hemopoietic function of mice was injured by cyclophosphamine, as indicated by decreases of contents of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), while platelets were not affected (P>0.05), as well as modification of organ indexes (P<0.05) and spleen antioxidant ability (P<0.05 or P<0.01), whereas sepia extract markedly increased the levels of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), but not platelets (P>0.05), and reversed the effects of cyclophosphamine on organ indexes and antioxidant ability of spleen (P<0.01 or P<0.05). In addition, squid ink extract did not change marrow hemopoiesis but improved the antioxidant ability of spleen in the animals. The data suggest that squid ink extract can protect the hemopoietic system from chemotherapeutic injury and could be employed to develop cell-protective drugs for use in clinical treatment of tumours.
Keywords: Squid ink; cyclophosphamine; hemopoiesis; mice
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Zhong, J.-P.; Wang, G.; Shang, J.-H.; Pan, J.-Q.; Li, K.; Huang, Y.; Liu, H.-Z. Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine. Mar. Drugs 2009, 7, 9-18.
Zhong J-P, Wang G, Shang J-H, Pan J-Q, Li K, Huang Y, Liu H-Z. Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine. Marine Drugs. 2009; 7(1):9-18.
Zhong, Jie-Ping; Wang, Guang; Shang, Jiang-Hua; Pan, Jiang-Qiu; Li, Kun; Huang, Yan; Liu, Hua-Zhong. 2009. "Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine." Mar. Drugs 7, no. 1: 9-18.