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Special Issue "Marine Drugs Studies in China"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 January 2009)

Special Issue Editors

Managing Editor
Dr. Shu-Kun Lin (Website)

MDPI AG, St. Alban-Anlage 66, CH-4052 Basel, Switzerland
Interests: Gibbs paradox; entropy; symmetry; similarity; diversity; information theory; thermodynamics; process irreversibility or spontaneity; stability; nature of the chemical processes; molecular recognition; open access journals
Assistant Editor
Ms. Tina Wang

MDPI Tongzhou Office, Room 2207, Jincheng Center, No. 21 Cuijingbeili, Tongzhou District, Beijing 101101, China
Phone: +86 10 59011009
Fax: +86 10 59011089

Keywords

  • marine drugs related research in the P. R. China

Published Papers (2 papers)

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Research

Open AccessArticle Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine
Mar. Drugs 2009, 7(1), 9-18; doi:10.3390/md7010009
Received: 19 September 2008 / Revised: 29 October 2008 / Accepted: 11 December 2008 / Published: 14 January 2009
Cited by 13 | PDF Full-text (278 KB) | HTML Full-text | XML Full-text
Abstract
To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females in each group. At the end of the experiment, animals were sacrificed to investigate organ indexes and antioxidant ability of the spleen, peripheral blood profile and quantities of bone marrow nucleated cells. Results showed that the hemopoietic function of mice was injured by cyclophosphamine, as indicated by decreases of contents of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), while platelets were not affected (P>0.05), as well as modification of organ indexes (P<0.05) and spleen antioxidant ability (P<0.05 or P<0.01), whereas sepia extract markedly increased the levels of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), but not platelets (P>0.05), and reversed the effects of cyclophosphamine on organ indexes and antioxidant ability of spleen (P<0.01 or P<0.05). In addition, squid ink extract did not change marrow hemopoiesis but improved the antioxidant ability of spleen in the animals. The data suggest that squid ink extract can protect the hemopoietic system from chemotherapeutic injury and could be employed to develop cell-protective drugs for use in clinical treatment of tumours. Full article
(This article belongs to the Special Issue Marine Drugs Studies in China)
Open AccessArticle Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China
Mar. Drugs 2009, 7(1), 24-44; doi:10.3390/md7010024
Received: 11 December 2008 / Revised: 12 January 2009 / Accepted: 21 January 2009 / Published: 3 January 2009
Cited by 97 | PDF Full-text (542 KB) | HTML Full-text | XML Full-text | Correction | Supplementary Files
Abstract
The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over [...] Read more.
The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 actinomycetes were isolated and of these approximately 20%, 5%, and 10% inhibited the growth of Human Colon Tumor 116 cells, Candida albicans and Staphylococcus aureus, respectively, while 3% inhibited protein tyrosine phosphatase 1B (PTP1B), a protein related to diabetes. In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. Representative bioactive isolates were characterized using genotypic and phenotypic procedures and classified to thirteen genera, notably to the genera Micromonospora and Streptomyces. Actinomycetes showing cytotoxic activity were assigned to seven genera whereas only Micromonospora and Streptomyces strains showed anti-PTP1B activity. We conclude that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes. Full article
(This article belongs to the Special Issue Marine Drugs Studies in China)

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Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
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