Next Article in Journal
Monoindole Alkaloids from a Marine Sponge Spongosorites sp.
Previous Article in Journal
Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5(2), 23-30; doi:10.3390/md502023
Article

Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

1,* , 1, 1, 1, 2, 2, 2 and 2,*
1 Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany 2 Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany
* Authors to whom correspondence should be addressed.
Received: 29 May 2007 / Accepted: 29 June 2007 / Published: 25 June 2007
(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)
View Full-Text   |   Download PDF [101 KB, uploaded 24 February 2015]   |   Browse Figures
SciFeed

Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
Keywords: sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin. sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Bringmann, G.; Gulder, T.A.M.; Lang, G.; Schmitt, S.; Stöhr, R.; Wiese, J.; Nagel, K.; Imhoff, J.F. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Mar. Drugs 2007, 5, 23-30.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert