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Mar. Drugs 2007, 5(2), 23-30; https://doi.org/10.3390/md502023

Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

1
Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany
2
Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany
*
Authors to whom correspondence should be addressed.
Received: 29 May 2007 / Accepted: 29 June 2007 / Published: 25 June 2007
(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)
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Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. View Full-Text
Keywords: sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin. sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin.
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Bringmann, G.; Gulder, T.A.M.; Lang, G.; Schmitt, S.; Stöhr, R.; Wiese, J.; Nagel, K.; Imhoff, J.F. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Mar. Drugs 2007, 5, 23-30.

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