Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

doi:10.3390/md502023

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Mar. Drugs 2007, 5(2), 23-30; doi:10.3390/md502023

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Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

Gerhard Bringmann^1,* , Tobias A. M. Gulder¹, Gerhard Lang¹, Stefanie Schmitt¹, Rüdiger Stöhr², Jutta Wiese², Kerstin Nagel² and Johannes F. Imhoff^2,*

¹ Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany ² Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany

* Authors to whom correspondence should be addressed.

Received: 29 May 2007 / Accepted: 29 June 2007 / Published: 25 June 2007

(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)

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Abstract: In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.

Keywords: sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin.

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Cite This Article

MDPI and ACS Style

Bringmann, G.; Gulder, T.A.M.; Lang, G.; Schmitt, S.; Stöhr, R.; Wiese, J.; Nagel, K.; Imhoff, J.F. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Mar. Drugs 2007, 5, 23-30.

AMA Style

Bringmann G, Gulder TAM, Lang G, Schmitt S, Stöhr R, Wiese J, Nagel K, Imhoff JF. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Marine Drugs. 2007; 5(2):23-30.

Chicago/Turabian Style

Bringmann, Gerhard; Gulder, Tobias A.M.; Lang, Gerhard; Schmitt, Stefanie; Stöhr, Rüdiger; Wiese, Jutta; Nagel, Kerstin; Imhoff, Johannes F. 2007. "Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A." Mar. Drugs 5, no. 2: 23-30.

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