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Special Issue "Marine Natural Products as Anti-Cancer Agents"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 May 2008)

Special Issue Editor

Guest Editor
Prof. Dr. Jordan K. Zjawiony

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, MS 38677, USA
E-Mail
Fax: +1 662 9156975
Interests: marine biotechnology; pharmacognosy; natural products; semisynthesis; medicinal chemistry

Published Papers (1 paper)

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Research

Open AccessArticle Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Mar. Drugs 2007, 5(2), 23-30; doi:10.3390/md502023
Received: 29 May 2007 / Accepted: 29 June 2007 / Published: 25 June 2007
Cited by 23 | PDF Full-text (101 KB) | HTML Full-text | XML Full-text
Abstract
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have
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In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. Full article
(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)

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