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Mar. Drugs 2007, 5(2), 31-39; doi:10.3390/md502031

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

1, 1, 3, 4 and 1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea 2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China 3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea 4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed.
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
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Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
Keywords: Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity. Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.

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