Next Article in Journal
Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
Previous Article in Journal
Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2007, 5(2), 31-39; https://doi.org/10.3390/md502031

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

1
College of Pharmacy, Pusan National University, Busan 609-735, Korea
2
College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China
3
College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea
4
Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
*
Author to whom correspondence should be addressed.
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
View Full-Text   |   Download PDF [116 KB, uploaded 24 February 2015]   |  

Abstract

Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity. View Full-Text
Keywords: Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity. Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity.
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top