Mar. Drugs 2007, 5(2), 31-39; doi:10.3390/md502031

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

1email, 1, 1, 3, 4 and 1,* email
Received: 5 June 2007; Accepted: 23 June 2007 / Published: 25 June 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
Keywords: Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity.
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MDPI and ACS Style

Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.

AMA Style

Bao B, Zhang P, Lee Y, Hong J, Lee C-O, Jung JH. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Marine Drugs. 2007; 5(2):31-39.

Chicago/Turabian Style

Bao, Baoquan; Zhang, Ping; Lee, Yoonmi; Hong, Jongki; Lee, Chong-O.; Jung, Jee H. 2007. "Monoindole Alkaloids from a Marine Sponge Spongosorites sp.." Mar. Drugs 5, no. 2: 31-39.

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