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Monoindole Alkaloids from a Marine Sponge Spongosorites sp.
AbstractSeven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
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Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.View more citation formats
Bao B, Zhang P, Lee Y, Hong J, Lee C-O, Jung JH. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Marine Drugs. 2007; 5(2):31-39.Chicago/Turabian Style
Bao, Baoquan; Zhang, Ping; Lee, Yoonmi; Hong, Jongki; Lee, Chong-O.; Jung, Jee H. 2007. "Monoindole Alkaloids from a Marine Sponge Spongosorites sp.." Mar. Drugs 5, no. 2: 31-39.