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Mar. Drugs 2007, 5(2), 31-39; doi:10.3390/md502031

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

1, 1, 3, 4 and 1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea 2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China 3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea 4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed.
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
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Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
Keywords: Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity. Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.

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