Next Article in Journal
Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
Previous Article in Journal
Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Mar. Drugs 2007, 5(2), 31-39; doi:10.3390/md502031

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

1, 1, 3, 4 and 1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea 2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China 3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea 4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed.
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
View Full-Text   |   Download PDF [116 KB, uploaded 24 February 2015]   |   Browse Figures


Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
Keywords: Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity. Marine sponge; Spongosorites; monoindole alkaloids; cytotoxicity.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Bao, B.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. Monoindole Alkaloids from a Marine Sponge Spongosorites sp.. Mar. Drugs 2007, 5, 31-39.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert