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Mar. Drugs 2007, 5(2), 6-22; doi:10.3390/md502006
Article

Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand

1,* , 2, 5, 2, 4 and 4
1 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal 2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal 3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand 4 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farmácia, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA
* Author to whom correspondence should be addressed.
Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007
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Abstract

The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells.
Keywords: Oceanapia sagittaria; kuanoniamines A and C; anticancer activity; cell cycle progression; apoptosis; anti-proliferation of human lymphocytes Oceanapia sagittaria; kuanoniamines A and C; anticancer activity; cell cycle progression; apoptosis; anti-proliferation of human lymphocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kijjoa, A.; Wattanadilok, R.; Herz, W.; Campos, N.; Nascimento, M.S.J.; Pinto, M. Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand. Mar. Drugs 2007, 5, 6-22.

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