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Mar. Drugs 2007, 5(2), 6-22; doi:10.3390/md502006
Article

Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand

1,* , 2, 5, 2, 4 and 4
1 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal 2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal 3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand 4 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farmácia, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA
* Author to whom correspondence should be addressed.
Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007
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Abstract

The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells.
Keywords: Oceanapia sagittaria; kuanoniamines A and C; anticancer activity; cell cycle progression; apoptosis; anti-proliferation of human lymphocytes Oceanapia sagittaria; kuanoniamines A and C; anticancer activity; cell cycle progression; apoptosis; anti-proliferation of human lymphocytes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kijjoa, A.; Wattanadilok, R.; Herz, W.; Campos, N.; Nascimento, M.S.J.; Pinto, M. Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand. Mar. Drugs 2007, 5, 6-22.

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