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Mar. Drugs 2018, 16(4), 137; https://doi.org/10.3390/md16040137

Bioactive Compounds from Posidonia oceanica (L.) Delile Impair Malignant Cell Migration through Autophagy Modulation

1
Dipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, viale Morgagni 50, 50134 Firenze, Italy
2
Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Università degli Studi di Firenze, viale Pieraccini 6, 50139 Firenze, Italy
3
Dipartimento di Scienze Veterinarie, Università degli Studi di Pisa, viale delle Piagge 2, 56124 Pisa, Italy
4
Centro Interuniversitario di Biologia Marina ed Ecologia Applicata “G. Bacci”, Viale N. Sauro, 4, 57128 Livorno, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 April 2018 / Revised: 18 April 2018 / Accepted: 19 April 2018 / Published: 21 April 2018
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Abstract

Posidonia oceanica (L.) Delile is a marine plant with interesting biological properties potentially ascribed to the synergistic combination of bioactive compounds. Our previously described extract, obtained from the leaves of P. oceanica, showed the ability to impair HT1080 cell migration by targeting both expression and activity of gelatinases. Commonly, the lack of knowledge about the mechanism of action of phytocomplexes may be an obstacle regarding their therapeutic use and development. The aim of this study was to gain insight into the molecular signaling through which such bioactive compounds impact on malignant cell migration and gelatinolytic activity. The increase in autophagic vacuoles detected by confocal microscopy suggested an enhancement of autophagy in a time and dose dependent manner. This autophagy activation was further confirmed by monitoring pivotal markers of autophagy signaling as well as by evidencing an increase in IGF-1R accumulation on cell membranes. Taken together, our results confirm that the P. oceanica phytocomplex is a promising reservoir of potent and cell safe molecules able to defend against malignancies and other diseases in which gelatinases play a major role in progression. In conclusion, the attractive properties of this phytocomplex may be of industrial interest in regard to the development of novel health-promoting and pharmacological products for the treatment or prevention of several diseases. View Full-Text
Keywords: Posidonia oceanica; autophagy; cell migration; gelatinase; HT1080 cell line Posidonia oceanica; autophagy; cell migration; gelatinase; HT1080 cell line
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Leri, M.; Ramazzotti, M.; Vasarri, M.; Peri, S.; Barletta, E.; Pretti, C.; Degl’Innocenti, D. Bioactive Compounds from Posidonia oceanica (L.) Delile Impair Malignant Cell Migration through Autophagy Modulation. Mar. Drugs 2018, 16, 137.

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