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Molecules 2018, 23(7), 1750; https://doi.org/10.3390/molecules23071750

TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba

1
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, 80131 Napoli, Italy
2
Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67571, Iran
3
Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67571, Iran
4
Epitech Group SpA, Saccolongo, 35030 Padova, Italy
5
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 13 July 2018 / Accepted: 15 July 2018 / Published: 17 July 2018
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Abstract

Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed of the known echinophorins A and B, embedding the very rare α-pyrone terminal, and of the new echinophorin D (3), including also three conjugated triple bonds. The chemical structures of these compounds were secured by detailed inspection of MS and 1D/2D NMR spectra. The isolated polyacteylenes were evaluated for their modulation of six thermo-TRP channels and they revealed a selective activity on TRPA1, an ion channel involved in the mediation of neuropathic and inflammatory pain. This is the first report on the activity of plant polyacetylenes on transient receptor potential (TRP) channels. View Full-Text
Keywords: Echinophora platyloba; polyacetylenes; echinophorins; TRPA1; inflammation Echinophora platyloba; polyacetylenes; echinophorins; TRPA1; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chianese, G.; Sirignano, C.; Shokoohinia, Y.; Mohammadi, Z.; Bazvandi, L.; Jafari, F.; Jalilian, F.; Schiano Moriello, A.; De Petrocellis, L.; Taglialatela-Scafati, O.; Rigano, D. TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba. Molecules 2018, 23, 1750.

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