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Mar. Drugs 2017, 15(8), 252; doi:10.3390/md15080252

Fatty Acid Profile Is Modulated by Dietary Resveratrol in Rainbow Trout (Oncorhynchus mykiss)

1
GMA-Gesellschaft für Marine Aquakultur mbH, Hafentörn 3, 25761 Büsum, Germany
2
Institute of Animal Breeding and Husbandry, University of Kiel, Olshausenstraße 40, 24098 Kiel, Germany
3
Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, 24118 Kiel, Germany
4
Department of Metabolism and Nutrition, Institute of Food Science, Food Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 18 July 2017 / Revised: 31 July 2017 / Accepted: 8 August 2017 / Published: 11 August 2017
(This article belongs to the Special Issue The Sources and Production of Polyunsaturated Fatty Acids)
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Abstract

To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the key enzyme in FA metabolism, and serves as a ligand for PPARα, a transcription factor regulating β-oxidation. Rainbow trout (36.35 ± 0.03 g) were randomly allocated into six groups and fed diets with reduced fish oil levels (F4 = 4%, F2 = 2% and F0 = 0% of dry matter) supplemented with 0.3% (w/w) RV (F4 + RV, F2 + RV and F0 + RV). RV significantly affected FA composition in liver tissue and whole fish homogenates. 20:5n-3 (EPA) and 22:6n-3 (DHA) were significantly increased whereas precursor FA were diminished in fish fed the F2 + RV and F0 + RV diets when compared to F4 + RV and F0. RV significantly elevated ∆6-desaturase protein levels in the livers of F0 + RV fed animals. Hepatic mRNA expression of ∆6-desaturase, PPARα, and its target genes were affected by the dietary fish oil level and not by dietary RV. The results of this study indicated a potential benefit of supplementing RV in fish oil deprived diets elevating n-3 FA levels in rainbow trout. View Full-Text
Keywords: CPT1; fish oil replacement; hepatic fatty acid synthesis; long chain polyunsaturated fatty acids; mRNA expression; phytochemical; PPARα CPT1; fish oil replacement; hepatic fatty acid synthesis; long chain polyunsaturated fatty acids; mRNA expression; phytochemical; PPARα
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Torno, C.; Staats, S.; Pascual-Teresa, S.; Rimbach, G.; Schulz, C. Fatty Acid Profile Is Modulated by Dietary Resveratrol in Rainbow Trout (Oncorhynchus mykiss). Mar. Drugs 2017, 15, 252.

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