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Special Issue "The Sources and Production of Polyunsaturated Fatty Acids"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 March 2018

Special Issue Editors

Guest Editor
Dr. Sami J Taipale

Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
Website | E-Mail
Interests: aquatic ecology; mixotrophy; fatty acids; algal applications
Guest Editor
Dr. Elina Peltomaa

Department of Environmental Sciences, University of Helsinki, Helsinki, Finland
Website | E-Mail
Interests: aquatic ecology; mixotrophy; fatty acids; algal applications

Special Issue Information

Dear Colleagues,

Recent studies have clearly shown the importance of polyunsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and their nutritional value for human health. Most of EPA and DHA are synthesized in aquatic environments since terrestrial plants synthesize only small amounts of long-chain polyunsaturated fatty acids. Furthermore, previous studies has shown that EPA and DHA synthesis is common only among some microalgal taxa. In this Special Issue “The Sources and Production of Polyunsaturated Fatty Acids” of Marine Drugs, we hope to discover the breadth and versatility of EPA and DHA synthesis in marine environments. Thus, we welcome all field and laboratory studies related to EPA and DHA production in marine systems. Further, papers comparing marine and freshwater PUFA sources are welcome, however the main focus of the paper needs to be in marine environments. We are interested in the new potential sources of EPA and DHA, as well sources that could be easily adopted on high biomass production. Diet polyunsaturated fatty acids (EPA and DHA) affect a wide variety of physiological processes in animals and humans. In this special issue, our goal is also to broaden the understanding on EPA and DHA in marine ecosystems and thus we invite also all studies related to that aspect to be submitted in this Special Issue of Marine Drugs.

Dr. Sami J Taipale
Dr. Elina Peltomaa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polyunsaturated Fatty Acids

  • EPA

  • DHA

  • Microalgae

  • Macroalgae

  • Marine Ecosystem

Published Papers (2 papers)

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Research

Open AccessArticle Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer
Mar. Drugs 2017, 15(9), 283; doi:10.3390/md15090283
Received: 8 August 2017 / Revised: 23 August 2017 / Accepted: 30 August 2017 / Published: 4 September 2017
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Abstract
Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the
[...] Read more.
Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. Methods: The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft. Results: Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily per os administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors. Conclusion: MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells. Full article
(This article belongs to the Special Issue The Sources and Production of Polyunsaturated Fatty Acids)
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Open AccessArticle Fatty Acid Profile Is Modulated by Dietary Resveratrol in Rainbow Trout (Oncorhynchus mykiss)
Mar. Drugs 2017, 15(8), 252; doi:10.3390/md15080252
Received: 18 July 2017 / Revised: 31 July 2017 / Accepted: 8 August 2017 / Published: 11 August 2017
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Abstract
To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces
[...] Read more.
To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the key enzyme in FA metabolism, and serves as a ligand for PPARα, a transcription factor regulating β-oxidation. Rainbow trout (36.35 ± 0.03 g) were randomly allocated into six groups and fed diets with reduced fish oil levels (F4 = 4%, F2 = 2% and F0 = 0% of dry matter) supplemented with 0.3% (w/w) RV (F4 + RV, F2 + RV and F0 + RV). RV significantly affected FA composition in liver tissue and whole fish homogenates. 20:5n-3 (EPA) and 22:6n-3 (DHA) were significantly increased whereas precursor FA were diminished in fish fed the F2 + RV and F0 + RV diets when compared to F4 + RV and F0. RV significantly elevated ∆6-desaturase protein levels in the livers of F0 + RV fed animals. Hepatic mRNA expression of ∆6-desaturase, PPARα, and its target genes were affected by the dietary fish oil level and not by dietary RV. The results of this study indicated a potential benefit of supplementing RV in fish oil deprived diets elevating n-3 FA levels in rainbow trout. Full article
(This article belongs to the Special Issue The Sources and Production of Polyunsaturated Fatty Acids)
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