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Mar. Drugs 2017, 15(9), 283; doi:10.3390/md15090283

Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

1
SCF Pharma, Ste-Luce, QC G0K 1P0, Canada
2
Department of Biology, Université du Québec à Rimouski, Rimouski, QC G5L 3A1, Canada
*
Author to whom correspondence should be addressed.
Received: 8 August 2017 / Revised: 23 August 2017 / Accepted: 30 August 2017 / Published: 4 September 2017
(This article belongs to the Special Issue The Sources and Production of Polyunsaturated Fatty Acids)
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Abstract

Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. Methods: The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft. Results: Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily per os administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors. Conclusion: MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells. View Full-Text
Keywords: EPA; colorectal carcinoma; apoptosis; VEGF; EGFR; HIF1α EPA; colorectal carcinoma; apoptosis; VEGF; EGFR; HIF1α
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Morin, C.; Rodríguez, E.; Blier, P.U.; Fortin, S. Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer. Mar. Drugs 2017, 15, 283.

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