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Mar. Drugs 2017, 15(3), 53; doi:10.3390/md15030053

Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors

1
Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Mt. Carmel, 31905 Haifa, Israel
2
The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
3
Bacteriology Group, International Centre for Genetic Engineering & Biotechnology, Padriciano 99, 34149 Trieste, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Sylvia Urban
Received: 27 January 2017 / Revised: 15 February 2017 / Accepted: 16 February 2017 / Published: 23 February 2017
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Abstract

Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors. This review covers the set of molecules showing QSI activity that were isolated from marine organisms, including plants (algae), animals (sponges, cnidarians, and bryozoans), and microorganisms (bacteria, fungi, and cyanobacteria). The compounds found and the methods used for their isolation are the emphasis of this review. View Full-Text
Keywords: quorum-sensing inhibitors; quorum quenching; marine natural products; antimicrobial resistance; N-acyl homoserine lactones quorum-sensing inhibitors; quorum quenching; marine natural products; antimicrobial resistance; N-acyl homoserine lactones
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Saurav, K.; Costantino, V.; Venturi, V.; Steindler, L. Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors. Mar. Drugs 2017, 15, 53.

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