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Mar. Drugs 2017, 15(11), 340; doi:10.3390/md15110340

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

1
CICECO—Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
2
Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo (CEBAL)/Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal
3
ICAAM—Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Universidade de Évora, Pólo da Mitra, 7006-554 Évora, Portugal
4
CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
5
FFUC—Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
6
ALGAplus—Prod. e Comerc. De Algas e Seus Derivados, Lda., 3830-196 Ílhavo, Portugal
7
QOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Received: 20 September 2017 / Revised: 19 October 2017 / Accepted: 23 October 2017 / Published: 1 November 2017
(This article belongs to the Special Issue Marine Lipids 2017)
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Abstract

Macroalgae have been seen as an alternative source of molecules with promising bioactivities to use in the prevention and treatment of current lifestyle diseases. In this vein, the lipophilic fraction of short-term (three weeks) cultivated Bifurcaria bifurcata was characterized in detail by gas chromatography–mass spectrometry (GC-MS). B. bifurcata dichloromethane extract was composed mainly by diterpenes (1892.78 ± 133.97 mg kg−1 dry weight (DW)), followed by fatty acids, both saturated (550.35 ± 15.67 mg kg−1 DW) and unsaturated (397.06 ± 18.44 mg kg−1 DW). Considerable amounts of sterols, namely fucosterol (317.68 ± 26.11 mg kg−1 DW) were also found. In vitro tests demonstrated that the B. bifurcata lipophilic extract show antioxidant, anti-inflammatory and antibacterial activities (against both Gram-positive and Gram-negative bacteria), using low extract concentrations (in the order of µg mL−1). Enhancement of antibiotic activity of drug families of major clinical importance was observed by the use of B. bifurcata extract. This enhancement of antibiotic activity depends on the microbial strain and on the antibiotic. This work represents the first detailed phytochemical study of the lipophilic extract of B. bifurcata and is, therefore, an important contribution for the valorization of B. bifurcata macroalgae, with promising applications in functional foods, nutraceutical, cosmetic and biomedical fields. View Full-Text
Keywords: Bifurcaria bifurcata; macroalgae; lipids; lipophilic compounds; diterpenes; antioxidant activity; anti-inflammatory activity; antibacterial activity Bifurcaria bifurcata; macroalgae; lipids; lipophilic compounds; diterpenes; antioxidant activity; anti-inflammatory activity; antibacterial activity
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Santos, S.A.O.; Trindade, S.S.; Oliveira, C.S.D.; Parreira, P.; Rosa, D.; Duarte, M.F.; Ferreira, I.; Cruz, M.T.; Rego, A.M.; Abreu, M.H.; Rocha, S.M.; Silvestre, A.J.D. Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties. Mar. Drugs 2017, 15, 340.

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