Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones
AbstractThe electrochemical response of four natural cytotoxic thiazinoquinones isolated from the Aplidium species was studied using conventional solution-phase and solid-state techniques, based on the voltammetry of immobilized particles methodology. The interaction with O2 and electrochemically generated reactive oxygen species (ROS) was electrochemically monitored. At the same time, a molecular modeling study including density functional theory (DFT) calculations was performed in order to analyze the conformational and electronic properties of the natural thiazinoquinones, as well as those of their reduced intermediates. The obtained electrochemical and computational results were analyzed and correlated to cytotoxic activity of these compounds, highlighting some features possibly related to their mechanism of action. View Full-Text
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Imperatore, C.; Cimino, P.; Cebrián-Torrejón, G.; Persico, M.; Aiello, A.; Senese, M.; Fattorusso, C.; Menna, M.; Doménech-Carbó, A. Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones. Mar. Drugs 2017, 15, 335.
Imperatore C, Cimino P, Cebrián-Torrejón G, Persico M, Aiello A, Senese M, Fattorusso C, Menna M, Doménech-Carbó A. Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones. Marine Drugs. 2017; 15(11):335.Chicago/Turabian Style
Imperatore, Concetta; Cimino, Paola; Cebrián-Torrejón, Gerardo; Persico, Marco; Aiello, Anna; Senese, Maria; Fattorusso, Caterina; Menna, Marialuisa; Doménech-Carbó, Antonio. 2017. "Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones." Mar. Drugs 15, no. 11: 335.
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