Pyran Rings Containing Polyketides from Penicillium raistrickii
AbstractFive new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 μM, respectively. View Full-Text
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Ma, L.-Y.; Liu, D.-S.; Li, D.-G.; Huang, Y.-L.; Kang, H.-H.; Wang, C.-H.; Liu, W.-Z. Pyran Rings Containing Polyketides from Penicillium raistrickii. Mar. Drugs 2017, 15, 2.
Ma L-Y, Liu D-S, Li D-G, Huang Y-L, Kang H-H, Wang C-H, Liu W-Z. Pyran Rings Containing Polyketides from Penicillium raistrickii. Marine Drugs. 2017; 15(1):2.Chicago/Turabian Style
Ma, Li-Ying; Liu, De-Sheng; Li, De-Guo; Huang, Yu-Ling; Kang, Hui-Hui; Wang, Chun-Hua; Liu, Wei-Zhong. 2017. "Pyran Rings Containing Polyketides from Penicillium raistrickii." Mar. Drugs 15, no. 1: 2.
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