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Mar. Drugs 2017, 15(1), 2; doi:10.3390/md15010002

Pyran Rings Containing Polyketides from Penicillium raistrickii

1
College of Pharmacy, Binzhou Medical College, Yantai 264003, China
2
The Hospital of Luzhong Mining Co., Ltd., Laiwu 271113, China
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 31 October 2016 / Revised: 14 December 2016 / Accepted: 15 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
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Abstract

Five new pyran rings containing polyketides, penicipyrans A–E (15), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 μM, respectively. View Full-Text
Keywords: Penicillium raistrickii; α-pyrone; isocoumarin; polyketides; saline soil-derived fungus Penicillium raistrickii; α-pyrone; isocoumarin; polyketides; saline soil-derived fungus
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Ma, L.-Y.; Liu, D.-S.; Li, D.-G.; Huang, Y.-L.; Kang, H.-H.; Wang, C.-H.; Liu, W.-Z. Pyran Rings Containing Polyketides from Penicillium raistrickii. Mar. Drugs 2017, 15, 2.

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