Asymmetric Total Synthesis of Ieodomycin B
AbstractIeodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-modified Evans aldol reaction and a chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde, as well as the generation of a lactone ring in a deprotection–lactonization one-pot reaction. View Full-Text
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Lin, S.; Zhang, J.; Zhang, Z.; Xu, T.; Huang, S.; Wang, X. Asymmetric Total Synthesis of Ieodomycin B. Mar. Drugs 2017, 15, 17.
Lin S, Zhang J, Zhang Z, Xu T, Huang S, Wang X. Asymmetric Total Synthesis of Ieodomycin B. Marine Drugs. 2017; 15(1):17.Chicago/Turabian Style
Lin, Shuangjie; Zhang, Jianting; Zhang, Zhibin; Xu, Tianxiang; Huang, Shuangping; Wang, Xiaoji. 2017. "Asymmetric Total Synthesis of Ieodomycin B." Mar. Drugs 15, no. 1: 17.
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