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Mar. Drugs 2016, 14(1), 4; doi:10.3390/md14010004

Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides

1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No.7 Nanhai Road, Qingdao 266071, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
College of Animal Science and Technology, Qingdao Agriculture University, No.700 Changcheng Road, Qingdao 266109, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 9 October 2015 / Revised: 14 December 2015 / Accepted: 17 December 2015 / Published: 29 December 2015
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [2961 KB, uploaded 29 December 2015]   |  

Abstract

Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. View Full-Text
Keywords: marine macroalgae; sulfated polysaccharides; structure features; immune enhancement; anti-AIV marine macroalgae; sulfated polysaccharides; structure features; immune enhancement; anti-AIV
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MDPI and ACS Style

Song, L.; Chen, X.; Liu, X.; Zhang, F.; Hu, L.; Yue, Y.; Li, K.; Li, P. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides. Mar. Drugs 2016, 14, 4.

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