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Mar. Drugs 2016, 14(2), 31; doi:10.3390/md14020031

Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis

Department of Ophthalmology, University Medical Center, University of Kiel, 24105 Kiel, Germany
Academic Editor: Paola Laurienzo
Received: 30 November 2015 / Revised: 12 January 2016 / Accepted: 22 January 2016 / Published: 3 February 2016
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

Fucoidan is a heterogeneous group of sulfated polysaccharide with a high content of l-fucose, which can be extracted from brown algae and marine invertebrates. It has many beneficial biological activities that make fucoidan an interesting candidate for therapeutic application in a variety of diseases. Age-related macular degeneration and diabetic retinopathy are major causes for vision loss and blindness in the industrialized countries and increasingly in the developing world. Some of the characteristics found in certain fucoidans, such as its anti-oxidant activity, complement inhibition or interaction with the Vascular Endothelial Growth factor, which would be of high interest for a potential application of fucoidan in age-related macular degeneration or diabetic retinopathy. However, the possible usage of fucoidan in ophthalmological diseases has received little attention so far. In this review, biological activities of fucoidan that could be of interest regarding these diseases will be discussed. View Full-Text
Keywords: fucoidan; age-related macular degeneration; diabetic retinopathy; oxidative stress; VEGF; complement fucoidan; age-related macular degeneration; diabetic retinopathy; oxidative stress; VEGF; complement
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Klettner, A. Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis. Mar. Drugs 2016, 14, 31.

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