Next Article in Journal / Special Issue
Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides
Previous Article in Journal
New Drugs from Marine Organisms in Alzheimer’s Disease
Previous Article in Special Issue
Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(1), 6; doi:10.3390/md14010006

Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 2 December 2015 / Revised: 13 December 2015 / Accepted: 21 December 2015 / Published: 29 December 2015
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [1534 KB, uploaded 29 December 2015]   |  

Abstract

Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through characterization and its immunological activity was investigated. MMPX-B2 consisted of d-glucose and d-galctose residues at a molar ratio of 3.51:1.00. The average molecular weight of MMPX-B2 was 510 kDa. This polysaccharide possessed a main chain of (1→4)-linked-α-d-glucopyranosyl residues, partially substituted at the C-6 position by a few terminal β-d-galactose residues or branched chains consisting of (1→3)-linked β-d-galactose residues. Preliminary immunological tests in vitro showed that MMPX-B2 could stimulate the murine macrophages to release various cytokines, and the structure-activity relationship was then established. The present study demonstrated the potential immunological activity of MMPX-B2, and provided references for studying the active ingredients in M. meretrix. View Full-Text
Keywords: Meretrix meretrix Linnaeus; polysaccharide; structure; immunological activity Meretrix meretrix Linnaeus; polysaccharide; structure; immunological activity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, L.; Li, H.; Qian, J.; He, Y.; Zheng, J.; Lu, Z.; Xu, Z.; Shi, J. Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus. Mar. Drugs 2016, 14, 6.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top