Next Article in Journal
Therapies from Fucoidan: An Update
Next Article in Special Issue
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation
Previous Article in Journal
Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities
Previous Article in Special Issue
Design of Chitosan-Grafted Carbon Nanotubes: Evaluation of How the –OH Functional Group Affects Cs+ Adsorption
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(9), 5901-5919; doi:10.3390/md13095901

Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres

1
Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain
2
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 5 August 2015 / Revised: 8 September 2015 / Accepted: 9 September 2015 / Published: 16 September 2015
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
View Full-Text   |   Download PDF [1277 KB, uploaded 16 September 2015]   |  

Abstract

A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5. View Full-Text
Keywords: chitosan; spray-drying; semi-solid formulation; antioxidant encapsulation chitosan; spray-drying; semi-solid formulation; antioxidant encapsulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Acosta, N.; Sánchez, E.; Calderón, L.; Cordoba-Diaz, M.; Cordoba-Diaz, D.; Dom, S.; Heras, Á. Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres. Mar. Drugs 2015, 13, 5901-5919.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top